Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Naso-Ethmoidal Angioleiomyoma: A Mini-Invasive Combined Endoscopic and Microscopic Surgical Approach
ISSN: 2161-119X
Otolaryngology: Open Access

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
  • Case Report   
  • Otolaryngol 2012, Vol 2(1): 110
  • DOI: 10.4172/2161-119X.1000110

Naso-Ethmoidal Angioleiomyoma: A Mini-Invasive Combined Endoscopic and Microscopic Surgical Approach

Casale Manuele1*, Errante Yuri2, Occhicone Filomena2, Incammisa Antonino, Rabitti Carla3, Beomonte Zobel Bruno2, Salvinelli Fabrizio1 and Quattrocchi Carlo Cosimo2
1Department of Otolaryngology, University Campus Bio-Medico of Rome, via Alvaro Del Portillo, Rome, Italy
2Department of Radiology, University Campus Bio-Medico of Rome, via Alvaro Del Portillo, Rome, Italy
3Department of Pathology, University Campus Bio-Medico of Rome, via Alvaro Del Portillo, Rome, Italy
*Corresponding Author: Casale Manuele, MD, PhD, Department of Otolaryngology, University Campus Bio-Medico of Rome-School of Medicine, Via Alvaro Del Portillo, 21-00128 Rome, Italy, Tel: 00390622541633, Fax: 003906225411964, Email:

Received: 15-Feb-2012 / Accepted Date: 06-Mar-2012 / Published Date: 12-Mar-2012 DOI: 10.4172/2161-119X.1000110


Angioleiomyomas (AL) of the nasal cavity and paranasal sinuses are extremely rare benign tumors, representing less than 1% of all leiomyomas in the human body [1]. Common sites are the uterus and the gastrointestinal tract [2]. It is very rare into the nasal-paranasal cavities (only fifteen cases are reported in the literature) due to the paucity of smooth muscle tissue in this site [3].

Because of its rarity, the literature of AL in the nasal cavity and paranasal sinus is reviewed and the management is discussed.

Case Report

A-40-year-old man was admitted to the Radiology Department of our institution for the evaluation of a palpable tender mass protruding at the right medial canthus. The patient had observed a slow growth of this mass, associated with progressive reduction of smell, right nasal obstruction an omolateral recurrent self limited nasal bleeding.

Ultrasound examination revealed a lobulated solid tissue with a rich homogeneous vascularity at the color-doppler. Nasal fibroendoscopic examination revealed an easily bleeding mass occupying the right nasal cavity completely. MRI confirmed a solid mass (38 x 28 x 28 mm) centered at the level of the right nasal cavity and anterior ethmoid cells, crossing the midline, with lateral involvement of the medial orbital wall and dislocation of the right peri-bulbar fat with cranial extension. Disruption of the right paramedian cortical bone of the anterior cranial fossa due to bone remodelling was observed at the contextual CT examination with coronal reformatted images (Figure 1). After gadolinium-containing contrast agent (Omniscan) intravenous administration, the lesion showed intense and homogeneous enhancement with tiny hypointense spots in the context of the lesion. The pathologic study revealed fragments of nasal mucosa with aspects of hyperaemia and mild inflammation.


Figure 1: MR/CT diagnostic work-up. Solid mass showed hypointense signal on sagittal T1 weighted images (A) with net and homogeneous enhancement after intravenous administration of gadolinium contrast agent on coronal (B) and axial (C) planes. CT images (D and E) demonstrated bone remodelling of the cribriform lamina and the medial wall of the right orbit.

Transnasal surgical resection was planned and performed as follows by S.F. through a combined use of endoscopy and microscopy approach. Cottonoids soaked in oxymetazoline solution were positioned in the nasal cavity and left in place for ten minutes. One percent lidocaine with 1:200 000 epinephrine was subsequently injected at the level of the root of the middle turbinate and of the uncinate process.

A completely endoscopic approach was not possible because tumour bleeding precluded identification of key endoscopic landmarks. A primary microscopic resection was thus performed, assisted by the use of 0, 30 and 45 degree telescopes to assure tumour resection from recesses not visualized microscopically.

The specimen was resected “en bloc”, with care taken that the dissection was carried out in the subperiosteal plane. The intraoperative histological examination ruled out the malignant tissue. A CSF fistula was created during division the adhesions between the mass and dura mater. The fistula was repaired under endoscope vision using an overlay technique with lower turbinate graft; fibrin glue was applied to stabilize the site, which was then covered with surgical absorbable hemostatic gelatine sponge. The nasal packing was removed on the second day. The postoperative recovery period was uneventful. Blood transfusions were unnecessary. The patient was discharged three days later.

Histological examination of the mass revealed the presence of vascular formations with thick muscular wall and abundant fibrous connective stroma, with a definite diagnosis of angioleiomyoma (Figure 2).


Figure 2: Pathological findings. A) Closely packed vascular channels are characterized by irregularly sized muscular wall surrounding lumina lined by normal endothelium. B) Immunostain for alpha smooth muscle actin (SMA) highlights closely compacted smooth muscle cells of the vascular wall.

One month after surgery MRI examination showed a solid tissue located at the ethmoidal vault with post-gadolinium enhancement. At the six and twelve months follow-up MRI examination, reduction of size and of gadolinium enhancement suggested the presence of postsurgical granulation tissue with no evidence of residual tissue (Figure 3).


Figure 3: Post-surgery follow-up. Solid tissue located at the ethmoidal vault with enhancement after intravenous administration of gadolinium contrast agent (A and B: axial CE T1 weighted images), shows size reduction at the 12 months follow-up.


We report a case of endo-scopic removal of a large naso-ethmoidal vascular leiomyoma with cortical bone disruption of the orbital and anterior cranial fossa.

Vascular leiomyomas of the nasal cavity and paranasal sinuses are extremely rare, making up less then 1% of all human leiomyomas. This rarity is partially due to the paucity of smooth muscle in the nasal cavity; three theories have been put forward for the origin of angioleiomyomas: from aberrant undifferentiated mesenchyme, from smooth muscle in the wall of blood vessels, or from both [4]. When they are in the nasal cavity, the most frequent location is the inferior turbinate [5]. Other reported sites include the nasal vestibule, within nasal polyps and from the nasal septum [6].

Histological classification of leiomyomas by the World Health Organization [1,7] includes: leiomyoma, angio-leiomyoma (vascular leiomyoma or angiomyoma) and epithelioid leiomyoma (bizarre leiomyoma and leiomyoblastoma). Angiomyomas may stem from surface or deep tissue. In both cases, the neoplasia seems to develop from the vessels’ smooth muscle [8]. Vascular leiomyomas are made up of bundles of relatively organized smooth muscle cells, permeated by thick walled vessels. The surface lesions are made mainly by thick wall vessels associated with proliferative muscle tissue. Deeper lesions are usually larger, probably because of a delay in diagnosis, and frequently present varied histological alterations which are not seen on the surface types. These alterations include an increase in cell number and build up of myxoid substance. Fibrosis, calcifications and giants cell reaction may also be observed. Morimoto (1973) classified these tumours histologically into three types: (i) capillary or solid, (ii) cavernous and (iii) venous. In the limbs, these tumours are mainly solid, while in the head and neck they are frequently of the venous type [8,9]. Histopathological differential diagnosis includes hemangioma, angiofibroma, fibromyoma, leiomyoblastoma, angiomyolipoma, vascular leiomyosarcoma [8].

There are, also, reports of malignant tumour variants of this line. Lack of mitosis seems to indicate the tumor’s benign characteristics [8]. Immunohistochemical tests have been used to identify vascular leiomyomas. These tumours grow slowly and may persist for a long time [10] as observed in our patient.

In the nasal cavity, the most frequently reported location of the vascular leiomyoma has been the inferior turbinate. According to Barr et al. [3], the high incidence of leiomyomas in the inferior turbinate may be attributed to the large local amount of contractile vascular tissue in the smooth muscle.

According to the literature, the most common symptoms are: nasal obstruction (56.25%), facial pain (25%) and headache (25%) [1,3,10- 13]. Progressive anosmia was the only clinical complaint in this case, due to the deep unusual location of the mass in our patient.

Treatment for these tumours is based on local resection, and there are no reports of recurrence after total excision [1,2,8,9].

Surgical approach by naso-sinusal endoscopic surgery or by lateral rhinotomy depends on tumour location and extension, as well as the need for a better bleeding control and surgeon’experience [1,9,10]. A preoperative CT scan is essential for the evaluation of extension to the paranasal sinuses, to look for bony erosion and to plan the most appropriate surgical approach. Our patient underwent to tumor “en bloc” removal by an endonasal combined microscopic endoscopic technique. We believe that endoscopic combined with microscopic approach allows to better achieve minimal invasiveness. The surgeon benefits from the depth-of-field and the three dimensional view magnified by the microscope. The endoscope, meanwhile, grants a close up view of the lesion and allows to inspect from the midline with the use of wide-angle lenses.


In cases of rare benign tumors of the naso-ethmoidal region, such as angioleiomyomas, a mini-invasive combined surgical approach avoids suffering a demolitive and disfiguring surgery as well as external scars of the facial skin.


  1. Bloom DC, Finley JC Jr, Broberg TG, Cueva RA (2001) Leiomyoma of the nasal septum. Rhinology 39: 233-235.
  2. Hanna GS, Akosa AB, Ali MH (1988) Vascular leiomyoma of the inferior turbinate - report of a case and review of the literature. J Laryngol Otol 102: 1159-1160.
  3. Barr GD, More IA, McCallum HM (1990) Leiomyoma of the nasal septum. J Laryngol Otol 104: 891-893.
  4. Meher R, Varshney S (2007) Leiomyoma of the nose. Singapore Med J 48: e275-e276.
  5. Batsakis JG (1979) Tumors of the Head and neck: Clinical and pathological considerations. (2nd edn), Baltimore: Williams and Wilkins Co., p. 354-356.
  6. Lijovetzky G, Zaarura S, Gay I (1985) Leiomyoma of the nasal cavity (report of a case). J Laryngol Otol 99: 197-200.
  7. Murono S, Ohmura T, Sugimori S, Furukawa M (1998) Vascular leiomyoma with abundant adipose cells of the nasal cavity. Am J Otolaryngol 19: 50-53.
  8. Nall AV, Stringer SP, Baughman RA (1997) Vascular leiomyoma of the superior turbinate: first reported case. Head Neck 19: 63-67.
  9. Khan MH, Jones AS, Haqqani MT (1994) Angioleiomyoma of the nasal cavity - report of a case and review of the literature. J Laryngol Otol 108: 244-246.
  10. Ardekian L, Samet N, Talmi YP, Roth Y, Bendet E, et al. (1996) Vascular leiomyoma of the nasal septum. Otolaryngol Head Neck Surg 114: 798-800.
  11. Fonseca MT, Araújo PAK, Barreiros AC (2002) Leiomyoma of the paranasal sinuses: a case report and review of the literature. Rev Bras Otorrinolaringol 68: 436-439.
  12. Daisley H (1987) Leiomyoma of the nasal cavity. West Indian Med J 36: 181-183.
  13. Sawada Y (1990) Angioleiomyoma of the nasal cavity. J Oral Maxillofac Surg 48: 1100-1101.
  14. Enzinger FM, Weiss SW (1983) Benign tumors in smooth muscle. In: Soft Tissue Tumors. C.V. Mosby Co., 282-285.

Citation: Casale M, Yuri E, Filomena O, Antonino I, Carla R, et al. (2012) Naso- Ethmoidal Angioleiomyoma: A Mini-Invasive Combined Endoscopic and Microscopic Surgical Approach. Otolaryngol 2:110. Doi: 10.4172/2161-119X.1000110

Copyright: © 2012 Casale M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Post Your Comment Citation
Share This Article
Recommended Conferences
Article Usage
  • Total views: 13579
  • [From(publication date): 3-2012 - Nov 29, 2023]
  • Breakdown by view type
  • HTML page views: 9262
  • PDF downloads: 4317
Share This Article