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37 studies summarizing information, CYP 2E1 (CYP-2E1 −1053C>T, CYP-2E1 -7632T>A) and 1B1 (CYP-1B1 L432V) polymorphisms were included in our meta-analysis. Random or fixed effect methods were used for the analysis. We calculated the odds ratios with their 95% confidence intervals to assess the association between CYP2E1 and 1B1 polymorphism and HNSCC risk. Using random or fixed effect methods, we found statistically significant association of CYP-2E1 −1053C>T, CYP-2E1 -7632T>A and CYP 1B1 polymorphisms with HNSCC risk without any evidence of publication bias or significant heterogeneity. A positive association was also found concerning CYP-2E1 −1053C>T, CYP-2E1 -7632T>A and HNSCC. In subgroup analyses by race, the same significant risks were found among Asian. However, no association was found for CYP-1B1 L432V in the development of HNSCC. Further studies may contribute to the investigation of the potential multigenetic predisposition of HNSCC and reinforce our findings.
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