alexa Achalasia Cardia Recent Advances in Diagnosis and Endoscopic Management | Open Access Journals
ISSN: 2161-069X
Journal of Gastrointestinal & Digestive System
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Achalasia Cardia Recent Advances in Diagnosis and Endoscopic Management

Zaheer Nabi* and Duvvur Nageshwar Reddy

Asian Institute of Gastroenterology, Hyderabad, Telangana, India

*Corresponding Author:
Zaheer Nabi
Consultant, Asian Institute of Gastroenterology
Gastroenterology, 6-3-661, Somajiguda
Hyderabad, Telangana 500082, India
Tel: 919573058810
E-mail: [email protected]

Received date: October 21, 2015; Accepted date: January 11, 2016; Published date: January 20, 2016

Citation: Nabi Z, Reddy DN (2016) Achalasia Cardia – Recent Advances in Diagnosis and Endoscopic Management. J Gastrointest Dig Syst 6:393. doi:10.4172/2161-069X.1000393

Copyright: © 2016 Nabi Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Gastrointestinal & Digestive System

Abstract

Achalasia Cardia is a rare neurodegenerative disorder of esophagus resulting in defective peristalsis and impaired relaxation of lower esophageal sphincter. The exact etiopathogenesis of achalasia is not known. Achalasia is associated with significant morbidity and impaired quality of life. The standard of care in patients with achalasia has been pneumatic balloon dilatation and laparoscopic heller's myotomy. Recent advancements in the diagnosis and endoscopic management have greatly improved the outcomes of this disorder. Subtyping of esophageal motility disorders with high resolution manometry has served to predict treatment outcomes and plan appropriate treatment. Per oral endoscopic myotomy (POEM) is an novel minimally invasive treatment option for all types of achalasia cardia. Short and mid term efficacy are excellent. Randomized trials are required to confirm its superiority over the currently established treatment modalities.

Keywords

Achalasia cardia; Per oral endoscopic myotomy; High resolution manometry; Timed barium esophagogram

Introduction

Achalasia Cardia (AC) is a primary motility disorder of the esophagus characterized by aperistalsis and defective lower esophageal sphincter relaxation. The pathogenesis of AC is poorly understood. However recent evidences indicate that it is an autoimmune process trigerred by some virus (e.g herpes virus) in a genetically predisposed individual resulting in degeneration of myenteric neurons [1].

Achalasia is a rare disease and therefore the epidemiological data on its incidence and prevalence is limited. The incidence and prevalence of AC in population studies is 0.31-1.63 and 6.29-10.82 per 105 population respectively [2-6]. The standard of endoscopic management has been graded pneumatic balloon dilatation and botox injection in selected high risk cases. Recent advances in the diagnosis as well as endoscopic management of AC have improved the outcomes significantly.

Diagnosis and Prediction of Outcomes

The diagnosis of AC relies on high resolution esophageal topography and endoscopy. Barium swallow supplements the diagnosis and is an objective parameter for documenting esophageal emptying after any therapeutic intervention. The main role of gastroscopy is to rule out other causes of dysphagia, especially pseudoachalasia due to gastroesophageal junction neoplasms.

High Resolution Manometry and High Resolution Impedance Manometry

High resolution manometry (HRM) has largely replaced conventional manometry for the diagnosis of AC and other motility disorders of esophagus. In HRM the pressure sensors are closely spaced (1 cm intervals) so that the esophageal pressure is depicted as a continuum in real time. HRM is the diagnostic modality of choice for AC and other non-achalasia motility disorders of esophagus. Chicago Classification (CC) of esophageal motility disorders is widely accepted for the subtyping of AC and defining other esophageal motility disorders of esophagus [7].

With HRM, three subtypes of AC have been identified (Type I, II, III) [8,9]. Subtyping of AC into three types has prognostic significance as well. Type II AC (panesophageal pressurisation) responds best to any form of treatment (botox injection, pneumatic dilatation, heller’smyotomy), whereas type I AC does not respond as well and type III is the most resistant to treatment [8,9]. The response rate to pneumatic balloon dilatation (PBD) in one study was 90.0% for type II AC as compared to 63.3% for type I and only 33.3% for type III AC [8]. There is some evidence that Type III AC responds better to myotomy than pneumatic dilatation (86% vs. 40%) [10]. Therefore, HRM may also help in deciding the optimum modality of treatment.

HRM can also predict the probability of recurrence after treatment (like PBD). A post dilatation lower esophageal sphincter (LES) pressure of <10 mmHg or >50% reduction in LES pressure from baseline is a predictor of good outcome and less chances of recurrence [11,12]. Esophageal HRM has been found to be equivalent to timed barium esophagogram (TBE) in assessing the efficacy of PBD in treatment of achalasia [13]. The normalization of integrated relaxation pressure (IRP) correlates well with TBE and has been found to be a valid objective point in treatment of AC [14].

Moreover, high-resolution impedance manometry (HRIM) can be used as a single test to determine bolus retention (like in TBE) and motility function in the management of achalasia [15]. The measurement of bolus flow time (BFT) by HRIM is an useful adjunct to integrated relaxation pressure (IRP) in the diagnosis of AC [16].

Therefore, HRM is an indispensable tool in the diagnosis and management of patients with AC and other esophageal motility disorders.

Timed Barium Esophagogram

Timed barium esophagogram (TBE) is an objective way to determine esophageal emptying. In TBE a fixed quantity (about 200-250 ml) of low density barium (45%) is ingested and films are taken at predefined intervals (1, 2 and 5 minutes) [17]. TBE has an important role in predicting treatment failure and symptom relapse in patients treated for achalasia (Figures 1 and 2). In a randomized trial, Andersson et al (2009) showed that in patients with less than 50% improvement in height of barium column at 1 min, the chance of failure was high (40%) during follow-up [18].

gastrointestinal-digestive-system-Pre-POEM

Figure 1: TBE - Pre POEM.

gastrointestinal-digestive-system-Post-POEM

Figure 2: TBE - Post POEM.

After a procedure, TBE is better than symptom relief or LES pressure in predicting future relapse [19-21]. In one study, Vaezi et al. (2002) found that about 30% of AC patients treated with PBD reported good immediate symptom relief despite poor esophageal emptying (<50%) on TBE. However, 90% of these patients relapsed within 1 year of follow up [19,20]. Therefore TBE identifies an important subgroup of patients who need close follow up or early re-treatment despite symptom control.

Endoluminal Functional Lumen Imaging Probe (EndoFLIP)

EndoFLIP works on the principle of impedence planimetry and allows the measurement of gastroesophageal junction (GEJ) distensibility in real time. GEJ diameter, cross sectional area and distensibility (calculated by dividing minimum cross-sectional area at the GEJ by pressure) can be measured with this novel technique. As expected, GEJ distensibility and cross sectional area increase substantially after successful treatment in patients with AC. The proposed advantage of this technique is that the adequacy or completeness of myotomy (endoscopic or heller) can be determined during the procedure. Establishing the adequacy of myotomy may be challenging during per-oral endoscopic myotomy (POEM). EndoFLIP may be useful in this regard as myotomy can be extended, if GEJ distensibility is inadequate [22].

The evidence for utility of endoFLIP in identifying the effect of myotomy on GEJ physiology is gradually building up [23-25]. The measurement of GEJ distensibillity by endoFLIP may be a better parameter than LES pressure to evaluate the efficacy of treatment in AC [24].

Teitelbaum et al. (2015) studied the effect of extent of myotomy on EndoFlip and concluded that extension of myotomy for 2 cm across GEJ normalizes GEJ distensibility during POEM. However, further extension of myotomy onto the gastric side (upto 3 cm) did not result in incremental compliance [25]. Therefore, EndoFLIP appears a promising novel innovation in assessing the success of endoscopic or surgical myotomy. However, more studies with long term follow up are required to assess the impact of this technique on the management of AC.

Management of Achalasia Cardia

AC can be managed but not cured. Since the initial description of AC in 1674 by Sir Thomas Willis, various endoscopic and surgical treatment modalities have been developed and modified from time to time. However, all of them aim to reduce the GEJ or LES pressure and none of these modalities can bring back the normal motility of esophageal body. This is because the degeneration of myenteric neurons, due to yet poorly understood reasons, underlies the pathogenesis of AC and cannot be reverted back with the currently available treatment options.

Botulinum Toxin Injection

Botolinum toxin injection (BI) has been in use for years now for AC. The proposed advantages being safety and good short term outcomes (>75%). However, the disadvantage being poor long term efficacy (35-41% at 1 year) [26].

Currently BI is used in specific patient groups (e.g high surgical risk, vigorous achalasia) who are not fit for pneumatic balloon dilatation (PBD) or myotomy. There is a renewed interest in the use of BI for non-achalasia esophageal motility disorders like diffuse esophageal spasm (DES) and nutcracker esophagus (NE). Vanuytsel et al. (2013) demonstrated the utility of BI in DES and NE in a prospective, doubleblind, randomized, controlled study. The authors used BI at two levels of esophagus (2 and 7 cm above GEJ) in this study. The response rate (improvement in dysphagia) at 1 month and 1 year was 50% and 30% respectively [27]. Therefore, BI may be especially useful in these patients who are otherwise difficult to treat.

Pneumatic Balloon Dilatation

Pneumatic Balloon Dilatation (PBD) is the standard of non surgical management of AC. Non compliant polyethylene balloons (Rigiflex, Boston Scientific) are used under fluoroscopic guidance to stretch LES. Graded dilatation is recommended to get the best results with PBD [26]. Dilatation is started with a 30 mm balloon with subsequent dilatations done with 35 and 40 mm balloons in case of symptom relapse or esophageal stasis on TBE. Older age (>40 years) and type II AC are predictive factors for good response [8-10]. The efficacy of PBD is comparable to heller’smyotomy at 2 years follow up (86% vs. 90%) [28]. The most feared complication of PBD is perforation which occurs in about 2-4% of cases. Risk factors for PBD related perforations include – age >65 years and initial dilatation with a larger balloon. However, most of these perforations can be managed conservatively [29,30].

Laparoscopic Heller Myotomy (LHM)

Heller myotomy has evolved and developed over time since its introuction more than a hundred years ago. To begin with, both an anterior and posterior myotomies were performed via abdominal approach [31]. Subsequently, myotomy via transthoracic route gained transient acceptance [32]. Difficulty in reaching on to the anterior wall of gastric cardia leading to insufficient myotomy is one of the major drawbacks with thoracoscopic approach.

With the advent of laparoscopic approach, the morbidity minimized significantly and LHM was accepted as the standard of surgical management for AC. However, worrisome gastroesophageal reflux remained a trouble. A limited myotomy (especially on the gastric side) would minimize reflux, but the chances of recurrent dysphagia would be high. In its current form, LHM is combined with partial posterior (Toupet) or anterior (Dor) fundoplication to limit GER and myotomy is extended to 6 cm on esophageal side and 3 cm on gastric side to limit occurrence of recurrent dysphagia [33]. Long term (≥5 years) success rates reported with LHM are 80-84% [34]. LHM has been found to be comparable to PBD (at 5 years) in the European achalasia trial. However a quarter of PBD patients required redilations on follow up [35].

Per Oral Endoscopic Myotomy (POEM)

Endoscopic myotomy was first described by Ortega and colleagues in 1980 [36]. Although the authors described the procedure as fast, safe and effective, it did not gain widespread acceptance because of the fear of complications like mediastinitis and perforation.

The development of NOTES reopened the doors of minimally invasive treatment for AC. Sumiyama and colleagues (2008) described a technique to safely access the peritoneal and mediastinal cavity. The principle of POEM is based on this technique called as submucosal endoscopy with mucosal flap safety valve technique [37].

Pasricha et al. (2007) first described the feasibility of submucosal endoscopic esophageal myotomy in a porcine model [38]. Subsequently Inoue et al. (2009), performed the first human submucosal endoscopic myotomy and coined the term POEM for this technique [39]. Since then a large number of studies have been published demonstrating the safety and efficacy of POEM in AC [40-52].

POEM – Technique

POEM is performed under general anaesthesia with the patient in supine position. The standard equipment or accessories used for POEM include – a high definition endoscope with water jet facility, transparent cap (Olympus), CO2 insufflator (UCR; Olympus), triangletip knife (Olympus) or hybrid knife T type (ERBE, Tübingen, Germany), coagulating forceps (Coagrasper, Olympus) and hemostatic clips.

The first and most important step is lifting the mucosa away from submucosa by injecting solution made of saline mixed with indigocarmine dye (Figure 3). This area is usually chosen about 10-15 cm proximal to GEJ. A good lift makes the next step of entry into submucosal tunnel easier.

gastrointestinal-digestive-system-lifting-injection

Figure 3: Submucosal lifting injection.

The next step involves making a mucosal incision and clearance of submucosal fibres to make way for the entry of gastroscope (Figure 4). Initially a small (3-4 mm) mucosal incision is made using a needle knife and subsequently the incision is enlarged by an insulated tip knife (Olympus) up to 2 cm in length [40].

gastrointestinal-digestive-system-Mucosal-Incision

Figure 4: Mucosal Incision.

In the third step, submucosal tunnel is created by using triangular tip or hybrid knife (Figure 5). Any intervening vessels are coagulated using the coagulation forceps (Figures 6a and 6b). The submucosal tunnel should extend to at least 2 to 3 cm beyond GEJ onto the gastric side for good relief. Adequate extension of tunnel can be confirmed by retroflex viewing of the gastric cardia and identifying the bluish discoloured area.

gastrointestinal-digestive-system-submucosal-tunnel

Figure 5: Creation of submucosal tunnel.

gastrointestinal-digestive-system-Large-vessel

Figure 6a: Large vessel encountered during tunnelling.

gastrointestinal-digestive-system-vessels-coagrasper

Figure 6b: Coagulation of vessels with coagrasper.

Myotomy is then performed, starting from 2 to 3 cm distal to the mucosal incision site (safety mucosal flap) (Figure 7).

gastrointestinal-digestive-system-Endoscopic-circular

Figure 7: Endoscopic circular only myotomy.

Either circular only myotomy or full thickness myotomy (both circular and longitudinal muscles) can be performed.

The authors perform circular only myotomy in the proximal part and full thickness myotomy in the lower part of esophagus (from 2-3 cm proximal to GEJ till the end of submucosal tunnel).

In the final step mucosal incision is closed using standard hemostatic clips (Figure 8). It is important to carefully inspect the esophageal mucosa for any inadvertent injury or perforation before closing the mucosal incision. After the procedure, patients are kept nil per oral for about 24 hours. A timed barium esophagogram is performed about 24 hours later and oral liquids are started subsequently.

gastrointestinal-digestive-system-mucosal-incision

Figure 8: Closure of mucosal incision with endoclips.

POEM – Variation in Techniques

POEM can be performed by an anterior (2’oclock) or posterior (5’ oclock) approach. Lower esophageal sphincter is asymmetric and consists of semicircular clasp like fibres on the right (centred at 2 O’clock) and oblique sling fibres on the left (5 to 11 O’clock) side of the esophagus. Therefore, in anterior myotomy only the clasp fibres are divided, whereas in posterior approach both the clasp and sling fibres are cut. A limited myotomy of the clasp fibres may not completely abolish the competency of GE junction due to persistent action of sling fibres [41]. Therefore, theoretically speaking a posterior approach should give better results in terms of symptom response. However, randomized control trials are required to demonstrate any clinically relevant differences in anterior vs. posterior myotomy. The authors prefer a posterior approach in patients with history of prior laparoscopic heller’smyotomy (LHM) or in case a diverticulum is present along the anterior esophageal wall.

Other variations in endoscopic myotomy include – full thickness vs. circular myotomy and short vs. long myotomy. Limited data suggests that there is no difference in the clinical outcomes and complications between full thickness vs. circular only myotomy. However, the procedure time may be shorter for full thickness myotomy [42,43].

Tang et al (2015), compared short myotomy (<7 cm) to long myotomy (>7 cm). Short term clinical efficacy were similar in the two groups and the procedure time shorter in the former group [44]. However, randomized trials are required before applying the results of this study into clinical practice. A shorter myotomy may be sufficient for type II AC, whereas a long myotomy is necessary for vigorous achalasia (type III) and other non-achalasia spastic disorders like DES and nutcracker esophagus.

At this point, the available evidence is limited to advocate any one technique over the other and future studies are required to demonstrate clinically relevant differences between various tecniques.

POEM – Efficacy and Complications

The efficacy and safety of POEM has been established in numerous retrospective and prospective studies (Table 1) [45-52]. In a study by Ramchandani et al (2015), including over 200 patients with AC, the technical success rate of POEM was 96%. At 1 year, clinical success rate was 92%. There was significant improvement of esophageal emptying on TBE (38.4 ± 14.0% vs. 71.5 ± 16.1% (P=0.001) and mean lower esophageal sphincter pressure (37.5 ± 14.5 mmHg vs. 15.2 ± 6.3 mmHg, P=0.001). There were no major adverse events [45].

  n Efficacy (%) Follow up
Ren et al. [39] 119 92 10.4
Inoue et al.  [40] 500 89 36
Zhou et al. [41] 205 97 8.5
Ramchandani et al. [38] 220 92 12
Werner YB et al. [42] 80 80 29
Sharata et al.  [43] 100 97 16

Table 1: POEM – efficacy in selected studies.

POEM is a safe procedure and till date no death has been reported related to this procedure. Intraprocedural events include – gas related (pneumothorax, capnoperitoneum, subcutaneous emphysema), mucosal injury, premature muscle injury and bleeding (Table 2). However, these events rarely proceed to clinically significant adverse events and no mortality has been observed due to any of these events [45-47,50-52].

  N Perforation Mucosal Inj Bleed Gas Related
Ren et al. [39] 119 0.80% Tunnel entry dehiscence NA 0.80% Pneumothorax -25 %
Emphysema-55 %
Pneumoperitoneum -39 %
Von Renteln et al. [44] 70 1% 4% 1 %, 1 % delayed bleed Emphysema  37 %
Pneumoperitoneum  50 %
Sharata et al. [43] 100 3% NA 1% 1%
Inoue et al. [40] 500 0.40% 1.20% 0.2 % - intra-operative 0.20%
0.6 %- post-operative
Ramchandani et al. [38] 225 NA 6.30% NA Pneumothorax -1.3 %
Emphysema- 14.2 %
Pneumoperitoneum - 25 %
Stavropoulos et al. [45] (Ipoems ) 841 6.70% NA 1% 8.30%

Table 2: Adverse events related to POEM.

POEM - Comparison with Other Treatment options

POEM is an evolving technique with impressive short term results. Good outcomes with POEM demand its comparison with already established techniques like PBD and LHM. Unfortunately, there is no randomized trial till date comparing POEM with other treatment modalities for AC. Limited data suggests that the efficacy of POEM is comparable to laparoscopic heller’smyotomy (LHM) in patients with AC [53,54]. The post-procure pain, intra-operative blood loss, and procedure time are less and return to normal activities faster with POEM as compared to LHM [55,56].

Another advantage of POEM over LHM is that longer myotomies can be performed easily as may be required in some patients with DES, jackhammer esophagus and type III AC [57]. A multicenter study compared POEM to LHM in patients with type III AC. Clinical response was significantly better, length of myotomy longer and adverse events significantly lower in the POEM group. The authors attributed better response rates with POEM to the ability to perform longer myotomies than LHM [57].

POEM in Special Population (Failed cases, Sigmoid Achalasia, Pediatric achalasia)

POEM has been successfully performed in previously failed cases (PBD, Botox inj. Or LHM). Studies show that there is no difference in the efficacy between treatment naïve or prior failure cases [58-61]. Moreover, re-POEM can be performed in patients who fail to respond with initial POEM [62].

Sigmoid esophagus is regarded as an advanced stage of AC and treatment outcomes with the standard modalities are not as good. POEM is feasible and safe with good short term results in sigmoid type AC [63].

The other population group which is difficult to treat is pediatric AC. LHM is the current gold standard for children with AC. There is growing evidence that POEM is safe and effective in this group also [64,65].

Self Expanding Metal Stents (SEMS)

SEMS are commonly used for benign or malignant esophageal strictures. Covered SEMS are removable and have steady radial expanding force. This lead some authors to study the utility of covered SEMS in AC [66-68]. In a recent study, fully covered SEMS (diameter of 2.0-2.5 cm and length of 5-7 cm) was used in fifty nine patients with AC. The stents were subsequently removed at 1 month. Clinical remission was 82% at 1 year and 49% at 3 years. There were no major adverse events [66].

SEMS have been shown to be superior to botulinum toxin injection and PBD [67,68].

However, the time is not yet ripe for the use of SEMS and more data is required before they can be recommended for AC.

Management of Achalasia – The Individualized Approach

The management of achalasia needs to be tailored according to the subtype of AC on HRM as well as the phenotype of patients. Young patients (<35-40 years) do not respond as well to PBD as their older counterparts [69].

Therefore, they should be preferably managed with LHM or POEM. Similarly in patients with type III achalasia or other spastic esophageal disorders, POEM or LHM should be preferred to PBD for similar reasons. POEM may be especially useful in this subgroup of patients as longer myotomies can be easily performed as compared to LHM [70]. More studies are required to assess and compare the efficacy of myotomy and pneumatic dilatation in each subtype of AC (Table 3).

  PBD LHM POEM
Type I AC 63.3-85%8,10 81%10 91.4%*
Type II AC 90-93%8,9,10 93-100%9,10 93.6%*
Type III AC 33.3-40%8,10 80-86%10,57 98%57
Overall Efficacy 44-84%35 57-89.3%35,71,74 80-97%45-50
Follow up (yrs) ≥5 years ≥5 years 1-3 years
GER 4%74 9-33%71 15-30%47,50,52,54

Table 3: Comparison of efficacy according to AC subtype. AC =achalasia cardia, PBD: Pneumatic Balloon Dilatation, POEM: Per Oral Endoscopic Myotomy, GER: Gastroesophageal reflux. *Study in Abstract form (Tang X et al. Volume 81, No. 5S: 2015 GASTROINTESTINAL ENDOSCOPY AB493).

Success rates of myotomy (endoscopic or surgical) may increase with the use of EndoFlip which will help in deciding the optimal length of myotomy intra-operatively. Timed barium esophagogram should be performed postprocedure, irrespective of the treatment modality used (LHM, PBD or POEM). It is an excellent predictor of future relapse, even if clinical symptoms are apparently absent [19].

Unfortunately, POEM has still not made its place in the management algorithms and guidelines on AC [26]. Excellent safety and efficacy of POEM in recent studies can not be ignored and it should find a definite place in the management of AC in near future (Figure 9).

gastrointestinal-digestive-system-near-future

Figure 9: Management of AC in near future.

Long Term Follow up and Surveillance - Why and How

Achalasia cardia is not curable because the currently available treatments do not restore the myenteric neurons which disappear over time. Moreover relapses are well known with the present treatment options (especially PBD and BI). Untreated relapses may lead to end stage achalasia for wchich esophagectomy may be required which carries significant morbidity. Therefore, regular follow up is required for these patients after treatment. Both, HRM and TBE have been utilized to follow these patients. TBE is non invasive and probably better than HRM for predicting future relapses. However, the frequency of performing the same is not known. Whether TBE should be performed at regular intervals (e.g. 6-12 monthly) after the procedure is a matter of debate. Arguments in favour include significant stasis and risk of disease progression in the absence of symptoms in some patients after the procedure. Early management will prevent the development of end stage achalasia. However, the strategy of treating patients solely on the basis of barium stasis on TBE in the absence of symptoms has not been formally tested. Nevertheless, this is a small subgroup of patients and routine TBE may not be justified in all. TBE at regular intervals may not be required in patients who have undergone LHM or POEM especially if intra-operative EndoFlip shows good relaxation and post procedure TBE shows good esophageal emptying. However, young patients and those with type I/III AC opting for PBD, require close surveillance and TBE at regular intervals may have some role.

In addition to disease relapse, additional reasons to follow the patients with AC include post treatment gastroesophageal reflux and risk of esophageal carcinoma [71-73].

Gastroesophageal reflux (GER) is a common occurrence after LHM and POEM. The incidence of GER ranges from 9-33% with LHM and 20-30% with POEM [71,72]. However, the reflux is usually mild and easily controlled with lifestyle modifications and proton pump inhibitors.

Achalasia cardia predisposes to esophageal malignancy due to chronic stasis and mucosal irritation. The long term risk of esophageal malignancy in primary AC was 3.3% (~70% males) in one study. Unfortunately only 1/3rd of them could undergo potential curative treatment [74].

It is not easy to differentiate between dysplastic lesions from the changes of stasis esophagitis that are commonly present in patients with AC. Therefore, the utility of surveillance endoscopy in AC is not well known and there is no consensus over the same. Whether the screening of selected high risk cases (e.g older men, >10 years of disease) and use of narrow band imaging or lugol’s iodine will improve the outcomes of screening remains to be seen.

Summary

Achalasia cardia is a rare neurodegenerative disease with significant morbidity. Recent advances in the diagnosis and management of AC have significantly improved the outcomes. High resolution manometry allows for the subtyping of AC and helps in guiding treatment plan. New diagnostic modalities like EndoFLIP allow intra-operative assessment of adequacy of myotomy. POEM is an novel endoscopic treatment option for AC. Short and midterm results with this technique are promising. However randomized trials are required to establish its superiority over other established modalities of treatment like LHM and PBD.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 9251
  • [From(publication date):
    February-2016 - Jun 28, 2017]
  • Breakdown by view type
  • HTML page views : 9029
  • PDF downloads :222

Review summary

  1. Clarissa Elmer
    Posted on Oct 05 2016 at 2:57 pm
    The authors reviewed endoscopic management of achalasia, especially technique of per oral endoscopic myotomy (POEM). This paper includes educational points of this entity.
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords