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Chondrosarcoma of Second Toe Distal Phalanx-A Case Report
ISSN: 2329-910X

Clinical Research on Foot & Ankle
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Chondrosarcoma of Second Toe Distal Phalanx-A Case Report

Gurumoorthy PG, Dinkar Rai BK*, Arvind Kumar SM and Chaitra V
Department of Orthopaedics, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
*Corresponding Author: Dinkar Rai BK, Department of Orthopaedics, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, Tel: +91-9894140052, Email: [email protected]

Received: 06-Jan-2018 / Accepted Date: 31-Jan-2018 / Published Date: 07-Feb-2018 DOI: 10.4172/2329-910X.1000259

Abstract

Chondrosarcoma is a relatively common primary malignant bone lesion. It is a malignant, relatively slow growing cartilage producing tumor. It forms approximately 10% of malignant primary bone tumors. However, it usually arises in long bones and truncal bones, whereas these tumors are uncommon in the hands and feet. The type are (A) Primary chondrosarcomas arises denovo from bone without any preexisting lesion. (B) Secondary chondrosarcomas when tumor arises from preexisting benign lesions of bone. Primary tumor is generally seen between 40 to 60 years of age. Secondary chondrosarcomas are more common in young adults.

Keywords: Chondrosarcoma; Tumor; Chondroblastoma; Bone; Neoplasm

Pathology of Chondrosarcomas

Central type

It is a lobulated, translucent, bluish whitish cartilaginous mass with in medullary cavity. Endosteal aspect of cortex appears eroded and scalloped. Tumor spreads widely through medullary cavity, its extent is greater than it appears on X-rays. As tumor penetrates the cortex it is temporarily delimited by periosteum. New reactive new bone is formed at the periphery of sub periosteal mass there by thickening the cortex. This is seen in slow growing and less malignant tumors.

In rapidly growing tumors periosteum is penetrated easily, so no reactive new bone formation. When a firm greyish tanned tissue without lobular configuration is found, it represents most malignant type. On removing the closely investing periosteum, the tumor appears lobulated, bluish white, shiny, opalescent or semi-translucent mass of firm texture or rubbery consistency.

The cut surface exhibits specks of calcification that impart a gritty sensation on palpation, gelatinous or myxoid areas and ragged cavities. The degree of calcification is greater in slower growing tumors.

Microscopic appearance

Histological features of cartilage should be noted to diagnose presence of a cartilaginous tumor. A normal chondrocyte is ellipsoid, ovoid or round in shape, has slightly scalloped surfaces. It contain a central, oval, sometimes indented nucleus with regularly distributed abundant chromatin and indistinct nucleolus.

Sarcomatous chondrocytes and their nuclei vary greatly in size, shape, number of nuclei and nucleoli chromatin content. Histology shows signs of malignancy including hyper cellularity, plumpness of nuclei, double nuclei in more than occasional cells, pleomorphism of cells and nuclei, hyperchromatism and mitotic figures. Mitotic figures are rare in low and medium grade tumors but are readily found in high grade tumors.

Radiological Features

Central tumors

The lesion is seen in metaphysic or diaphysis of a long tubular bone. Rarely it may occupy epiphysis at juxtraarticular area, where it may be mistaken for a gaint cell tumor or chondroblastoma. The lesion is located in medullary cavity, it is large and ill defined. Countour of bone is enlarged or expanded. The cortex is focally or extensively eroded and thinned out. The inner cortex may have scalloped borders. Tumors will have specks of calcification and cotton whorl appearance. Slow growing tumors will show a greater of calcification where as highly malignant rapidly growing tumors will show little or no calcification and often destroys the cortex without expanding shaft. There is a associated soft tissue mass.

Low grade features

Dense calcification forming rings or specules with eccentric lobular growth of a soft tissue mass

High grade features

Faint amorphous calcifications with large non calcified areas and concentric growth of soft tissue mass.

This article presents the case of a 60-year-old woman with a chondrosarcoma in the distal phalanx of the left second toe. Radiography showed bony mass extending from the distal phalanx. Histologically, the tumor was classified as grade 1 chondrosarcoma [1-6].

Case Report

• A 60 years old lady presented with pain and swelling of the left second toe for the past 1 year.

• Insiduous onset and Gradually progressive

• No rest pain/night cries/constitutional features

• No other swellings in body

• k/c/o Type 2 diabetics and systemic hypertension for the past 2 years on regular medication

Local examination (left 2nd toe)

• Irregular well defined Swelling over the distal phalanx 2 × 3 cms.

• Minimal deep tenderness, No warmth.

• Heterogenous consistency ranging from firm to bony hard.

• Adherent to underlying soft tissues and Immobile.

• Non pulsatile, Non fluctuant and Opaque.

• ROM–full range (Figure 1).

clinical-research-foot-ankle-Local-examination

Figure 1: Local examination (left 2nd toe).

Figure 2 shows expansile chondroid matrix leision involving the distal phalanx of the second toe not involving the articular surface and no soft tissue infiltration.

clinical-research-foot-ankle-Lateral

Figure 2: X-ray 2nd toe AP/Lateral.

Plan

Patient was taken up for excision biopsy under local anesthesia and using Ray’s amputation technique disarticulation of the second toe at MTP joint (Figure 3).

clinical-research-foot-ankle-Plan

Figure 3: Plan.

Histologically

Sections show fragments of bone with an infiltrating neoplasm composed of nodules of cartilaginous tissue with varying cellularity (hypercellular). The chondrocytes have moderate amount of cytoplasm mildly atypical hyperchromatic nucleus and few showing prominent nucleoli. Binucleate and trinucleate chondrocytes are seen. The cartilaginous matrix appears thin and mucoid at places. The tumour seen permitting the cortical bone causing bone entrapment (Figure 4).

clinical-research-foot-ankle-Histology

Figure 4: Histology.

Discussion

Chondrosarcoma of the foot is rare. Correct classification of the grade of chondrosarcoma is extremely important because the prognosis and treatment are different for different stages and grades (Table 1). Evans et al. used their own grading system: low grade is a low-levelmalignancy, intermediate grade is moderately malignant, and high grade is highly malignant. The chondrosarcoma of the phalanx is rare but, when present, extirpation is necessary to prevent growth and spread. Therefore, every effort should be made to differentiate between enchondroma and chondrosarcoma in each case. Complete wide excision of the lesion and cartilage cap should not be violated during resection of chondrosarcoma arising out of osteochondroma as it will increase the risk of local reccurence.

 Grade Tumor Symptoms Prognosis Treatment
Benign Enchondroma Osteochondroma Usually no symptoms Execellent Surveillance, intralesional excision if symptomatic
Malignant (Low grade) Grade 1 Chondrosarcoma 60% are painful Execellent Controcersial: Extended intralesional excision vs. wide resection
Malignant (Low grade) Grade 2 Chondrosarcoma Up to 80% are painful Good Wide resection
Malignant (intermediate garde) Grade 3 Chondrosarcoma Up to 80% are painful Fair Wide resection. Chemotherapy and radiation therapy in selected cases
Malignant (High grade) De-differentiated Chondrsarcoma Most are painful Poor Wide resection. Chemotherapy when possible in all cases. Radiation therapy in selected
Malignant (High grade) Mesenchymal Chondrosarcoma Pain and swelling Fair-Poor Wide resection. Chemotherapy in all cases.

Table 1: Classification [6].

Prognosis: Tumor arising in osteochondromas have excellent prognosis. Secondary chondrosarcomas arising in enchondramatosis have same prognosis as that of conventional chondrosarcomas [1-6].

Conclusion

Phalangeal chondrosarcoma behaves as locally aggressive lesion and rarely metastasize. Curettage with local adjuvant and adequate followup can be tried as the first-line management, especially where amputation would lead to significant loss of function.

References

Citation: Gurumoorthy PG, Rai BKD, Arvind Kumar SM, Chaitra V (2018) Chondrosarcoma of Second Toe Distal Phalanx-A Case Report. Clin Res Foot Ankle 6: 259. DOI: 10.4172/2329-910X.1000259

Copyright: ©2018 Gurumoorthy PG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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