Critical Appraisal of Subgroup Analysis
Received Date: Jan 08, 2016 / Accepted Date: Jan 15, 2016 / Published Date: Jan 22, 2016
In the subgroup analysis is performed by separating the data for patient subgroups, such as those in different stages, with different comorbidities and ages. Table 1 shows the checklist needed to make a critical analysis of subgroup analysis [1-8].
|The hypothesis was before or after the analysis?|
|The difference between subgroups was one of a small number of hypotheses tested effects?|
|The difference between the subgroups is suggested by comparison intra studies?|
|What is the magnitude of the difference between subgroups?|
|The difference between subgroups is consistent among the analysed studies?|
|The difference between subgroups is statistically significant? The appropriate statistical test was used?|
|There is external evidence that supports the hypothesis of difference between subgroups?|
|There is constant interaction between the results found and previous studies?|
|Conflicts of interest are declared.|
High quality (++): Majority of criteria met. Little or no risk of bias.
Acceptable (+): Most criteria met. Some flaws in the study with an associated risk of bias.
Low quality (-): Either most criteria not met, or significant flaws relating to key aspects of study design.
Reject (0): Poor quality study with significant flaws. Wrong study type. Not relevant to guideline.
Table 1: Critical appraisal of subgroup analysis.
Use this checklist can improve the evaluation of subgroup analysis.
- Guyatt G, Meade MO, Cook DJ, Rennie D (2014) Users' Guides to the Medical Literature: A Manual for Evidence-based Clinical Practice, Third edition. New York.
- Sackett DL, Richardson WS, Rosemberg WS, Rosenberg W, Haynes BR (2010) Evidence-Based Medicine: how to practice and teach EBM. Churchill Livingstone.
- Whiting P,Savovic J,Higgins JP,Caldwell DM,Reeves BC, et al. (2016) ROBIS: A new tool to assess risk ofbiasin systematic reviews was developed. J ClinEpidemiol 69:225-234.
- Higgins JPT, Altman DG, Gøtzsche PC, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomized trials. BMJ 343:d5928.
- Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155: 529e36.
- Sterne JAC, Higgins JPT, Reeves BC (2014) on behalf of the development group for ACROBAT- NRSI, A Cochrane Risk of Bias Assessment Tool: for Non-Randomized Studies of Interventions (ACROBATNRSI).
- Lawrentschuk N, McCall J, Güller U (2009) Critical appraisal of meta-analyses: an introductory guide for the practicing surgeon. P atient SafSurg 3: 16.
Citation: Roever L, Oliveira BFG (2016) Critical Appraisal of Subgroup Analysis 1: e115. Doi: 10.4172/2471-9919.1000e115
Copyright: © 2016 Roever L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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