Diagnosis and Differential Diagnosis of Primary Polydipsia
Received: 02-Mar-2022 / Manuscript No. jcds-20-58400 / Editor assigned: 04-Mar-2022 / PreQC No. jcds-20-58400 (PQ) / Reviewed: 10-Mar-2022 / QC No. jcds-20-58400 / Revised: 15-Mar-2022 / Manuscript No. jcds-20-58400 (R) / Accepted Date: 18-Mar-2022 / Published Date: 22-Mar-2022 DOI: 10.4172/jcds.1000138
Letter
Essential polydipsia (PP) is portrayed by an expanded liquid admission and reliable discharge of significant amounts of weaken pee surpassing 40-50 ml/kg body weight (e.g., 3000 ml/day for an individual of 60 kg) over a lengthy period, barring purposes behind optional polydipsia. It has most ordinarily been depicted in patients with schizophrenia range jumble with an occurrence of 11 to 20%, and has in this way been named psychogenic polydipsia [1]. With the rising prominence of way of life programs and the normal origination that consuming a few liters of liquid each day is sound, the commonness of this peculiarity is expanding, especially outside of the mental setting. Be that as it may, the pervasiveness in the general populace is obscure and still can’t seem to be considered. Probably, an absence of information in regards to the weight, outcomes and treatment choices for this issue has restricted examinations in this field as of recently.
The main differential diagnosis for primary polydipsia is diabetes insipidus (DI). The diagnostic method that has been used for a long time is the indirect water deprivation test (WDT), which is an indirect measurement of the arginine vasopressin (AVP) activity, combined with the administration of desmopressin. This test differentiates primary polydipsia from diabetes insipidus and also helps differentiate central from nephrogenic diabetes insipidus. However, this traditional test is not without flaws. Various new methods have been recently proposed and are being considered as the latest diagnostic standard for the diagnoses mentioned above. These tests include copeptin measurement at baseline and after hypertonic saline infusion, the other method being the measurement of copeptin at baseline and after arginine infusion [2].
Regarding the treatment of this condition, there is not one particular proven strategy. The recommended treatment is to control the water intake, but this poses a compliance problem, especially in patients with psychogenic polydipsia with compulsive behavior. Changes in medications that have anticholinergic side effects can be tried. Various classes of drugs have been studied, and none is effective. Behavioral treatment trials showed mixed results. Coordination and inter-professional approach can help treat the patients better [3].
The differential findings of essential polydipsia (PP) are focal and nephrogenic diabetes insipidus (DI). While PP is basically portrayed by expanded liquid admission, not entirely settled by polyuria due to hindered AVP discharge (focal DI) or AVP obstruction in the kidneys (nephrogenic DI). Focal DI might be procured after e.g., pituitary injury (medical procedure), contaminations, auto-resistant sickness or innate variables. Nephrogenic DI can be because of acquired transformations in the AVP-receptor-2 and aquaporine-2 quality, or obtained (e.g., persistent lithium use or metabolic/vascular kidney wounds). The initial phase in the finding and differential analysis of PP is an intensive history, including clinical and mental comorbidities and prescription. Contrasted with patients with DI, polydiptic patients commonly report a less intense beginning and regularly deny nocturia and drinking during the evening. The following indicative advance is to avoid different types of polyuria (e.g., diabetes mellitus) and to gauge plasma, pee osmolality and electrolytes. Low typical plasma sodium within the sight of a low pee osmolality is demonstrative of PP [4]. The broadly acknowledged highest quality level for the differential determination of PP is the circuitous water hardship test, presented in 1964. The test by implication surveys AVP movement by estimation of urinary osmolality, and accordingly the focus limit of the kidneys, during a delayed drying out period, and wraps up by evaluating the reaction (expansion in urinary osmolality in %) to the organization of exogenous vasopressin (desmopressin). In any case, this system is restricted by poor indicative precision of 70% generally and particularly poor symptomatic presentations of just 41% for PP. Thusly, different techniques have been examined. Direct estimation of AVP was utilized with at first encouraging outcomes. Be that as it may, because of estimating challenges and the flimsiness of AVP, direct estimation of AVP has never entered ordinary practice. Copeptin, the c-terminal piece of the AVP antecedent peptide, was viewed as a steady, touchy and handily estimated proxy marker for AVP [5].
Acknowledgment
The author would like to acknowledge his Department of Nephrology from the University of Stanford for their support during this work.
Conflicts of Interest
The author has no known conflicts of interested associated with this paper.
References
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Citation: Cruiser A (2022) Diagnosis and Differential Diagnosis of Primary Polydipsia. J Clin Diabetes 6: 138. DOI: 10.4172/jcds.1000138
Copyright: © 2022 Cruiser A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.
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