alexa Influence of Pneumococcal Conjugate Vaccine on Otitis Media | OMICS International
ISSN: 2161-119X
Otolaryngology: Open Access

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Influence of Pneumococcal Conjugate Vaccine on Otitis Media

Masaru Kunimoto1,2*, Sachio Takeno1, Katsuhiro Hirakawa1, Hirotoshi Sugino3 and Takahiro Sumiya4

1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Applied Life Sciences, Hiroshima University, Hiroshima City, Japan

2Kunimoto ENT Clinic, Hiroshima City, Japan

3Sugino Pediatric Clinic Hiroshima City, Japan

4Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima City, Japan

Corresponding Author:
Kunimoto M
ENT Clinic, 7-59-28, Tomohigashi
Asaminamiku, Hiroshima City, 731-3164, Japan
Tel: 81-82-811-8133
Fax: 81-82-811-8032
E-mail: [email protected]

Received Date: May 09, 2016; Accepted Date: May 23, 2016; Published Date: May 30, 2016

Citation: Kunimoto M, Takeno S, Hirakawa K, Sugino H, Sumiya T (2016) Influence of Pneumococcal Conjugate Vaccine on Otitis Media. Otolaryngol (Sunnyvale) 6:236. doi:10.4172/2161-119X.1000236

Copyright: © 2016 Kunimoto M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Otolaryngology: Open Access

Otitis Media

Streptococcus pneumoniae is considered as the prime causative pathogen responsible for pneumonia, bacteremia, meningitis, acute sinusitis, acute otitis media (AOM), and specifically pneumococcal disease which are invasive in nature.

The vaccine developed for pneumococcal diseases is a heptavalent conjugate vaccine (PCV 7). This particular vaccine consists of capsular polysaccharides originated from seven different Streptococcus pneumoniae species along with the protein diphtheria crm197 as conjugate antigens. In a month time after inoculation in children this vaccine is able to increase the IgG level sufficiently to combat the pneumococcal infections.

There are many designed cohort studies that evaluate the effectiveness of PCV7 for IPD and otitis media. In those studies, PCV7 are significantly reducing the invasive pneumococcal disease especially under 1 year children [1]. But PCV7 effect for acute otitis media and otitis media with effusion shows the unexpected results.

First, almost all studies about PCV7 effects for AOM are evaluated with terms of changes in episodes and altogether visits with medical purpose done by the children to the physician.

In 2012, Taylor et al. [2] reported meta-analysis of PCV7 effects against AOM that PCV7 provides some protection against OM on allcause AOM (aAOM) episodes and physician visits.

In 2014, the Cochrane repository reported an update about a metaanalysis of PCV effects on AOM [3]. One of the author’s major conclusions is that the PCV7 had modest beneficial effects. In 2015, it is not meta-analysis but Lau et al report form the United Kingdom shows the 22% reduction in children aged <10 years old [4]. From those results, PCV7 does not consider to have strong effect for AOM prevention.

Rate of myringotomy for acute otitis media per 1,000 populationyears in age groups, according to year. Total number of cases is 1,916 in the Figure 1. Public funding for PCV7 was introduced in January 2011.

Figure

Figure 1: Rate of myringotomy for acute otitis media (modified figure originally come from Sugino H, et al. [19]).

The rate in 1 year old children was significantly lower in 2011 and 2012 compared to 2008, 2009 and 2010 with chi-squared tests and Ryan's multiple comparison tests (asterisks). This is a modified figure. The second, numerous studies have evaluated changes in the number of ventilation tube insertion (VTI) to treat the recurrent otitis media and otitis media with effusion after PCV7 introduction under a typical vaccination schedule [5-14]. In long-term observations, almost all articles demonstrated that the number of VTI performed in ≤ 2 year old children significantly decreased after the introduction of PCV7 under a typical vaccination schedule.

The rate of reduction is 13%-50% [5-13]. But it is remarkable that inoculation is started over 1 year old; there is no significant effect in suppressing VTI even with the combined usage of a 23-valent pneumococcal polysaccharide booster [15-17]. From those results, PCV7 started in infants consider to have strong effect to prevent the complex otitis media required VTI.

These two results lead the question how PCV7 inoculation started under 1 year old children reduce the VTI if PCV7 has any work for AOM. This is why the AOM progression should be evaluate after introduction of PCV7.

Stamboulidis reported decreased rate of visit to the emergency department of clinics by 38% (from 133 to 83) for the patients having AOM in combination with otorrhea after successful PVC7 immunization [18].

Based on the finding on local inflammation, Sugino et al. [19] described the requirement of proper evaluation with relation to the AOM post PCV7 introduction applying number of myringotomies executed.

According to the recommendation of Japanese medical guidelines, AOM associated with stark otoscopic outcomes are referred for myringotomy. Similar recommendation is done for cases with report of treatment-resistance. Similar type of judgment is not given for the bacterial exam [20].

A total of 895 myringotomies were performed for 1 year old infants. The rate of myringotomies per child-year performed for acute otitis media in 1 year old infants went down considerably within the 2 years after receiving of the public funding rather than the years prior to the introduction (p<0.000001). We expect many new reports about the change of AOM progression after PCV introduction. And those results will show that pneumococcal conjugate vaccine may help prevent AOM from magnification having serious clinical manifestations and it may present some hypothesis to reduction of VTI for complex otitis media.

Acknowledgement

This work was partly supported by JSPS KAKENHI Grant Number 16K11213.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 8172
  • [From(publication date):
    June-2016 - May 22, 2018]
  • Breakdown by view type
  • HTML page views : 8102
  • PDF downloads : 70
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected].com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7