alexa New Era of Low Carbohydrate Diet (LCD) and Ketone Bodies (KB) as Energy Source | OMICS International
Journal of Clinical and Experimental Endocrinology
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

New Era of Low Carbohydrate Diet (LCD) and Ketone Bodies (KB) as Energy Source

Hiroshi Bando*

Tokushima University, Tokushima, Japan

*Corresponding Author:
Hiroshi Bando
Instructor of Tokushima University
Tokushima, Japan
Tel: +81-90-3187-2485
E-mail: [email protected]

Received Date: Sep 19, 2017; Accepted Date: Sep 21, 2017; Published Date: Sep 28, 2017

Citation: Bando H (2017) New Era of Low Carbohydrate Diet (LCD) and Ketone Bodies (KB) as Energy Source. J Clin Exp Endocrinol 1: e103.

Copyright: © 2017 Bando H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Clinical and Experimental Endocrinology

Editorial

Historically speaking, primitive man had evolved to human race, in which they had always fighted with hunger for several million years. What did they live on? They could sometimes hunt animals and ate meat, bone, visceral organ and bone marrow. This food consists of protein and fat with less carbohydrate. That is the reason why human body has only insulin that decreases blood glucose.

About 10,000 years ago, agriculture changed our lifestyle. They began to make crops such as rice, wheat, corn which is carbohydrate. As the result, the population on the earth increased explosively, and several civilizations were born where people continued hard work. On 18th century, industrial revolution changed our lifestyle with less manual labors and postprandial hyperglycemia due to refined crops by milling technology. On last 20th century, computerized society made us immobilization tendency.

Consequently, metabolic syndrome became urgent problem. International Diabetes Federation (IDF) summarized the current situation in the world [1,2]. Diabetic prevalence will increase from 8.8% in 2015 to 10.4% in 2040. Top 5 countries are China, India, USA, Brazil, Russian Federation, and high prevalence of 23-35% are observed in Qatar, Kuwait, Saudi Arabia, Micronesia and Marshall island. Taking this situation into consideration, to prevent and treat obesity and diabetes is crucial, where low carbohydrate diet (LCD) is effective for weight reduction and diabetic control [3-5].

It was previously believed that brain can generate energy from only glucose. However, it was proved to be wrong. At present, correct understanding has been spread that KB generates energy at brain and muscles, and KB has important role of human metabolism.

In 1910-1920, fasting therapy with metabolic changes of hormones and free fatty acid (FFA) was studied. It showed beneficial effects for various diseases, probably due to elevated KB 6). Starvation revealed that β-hydroxybutyrate (3-hydroxybutyric acid, 3-OHBA) replaced glucose as a source of energy with various metabolic changes including a switch in cell fuel from glucose to fatty acids [7-10]. KB inhibits amino acid metabolism and protein turnover in skeletal muscles, which may be survival mechanism during adaptation to catabolic states such as fasting [10-12].

Authors and colleagues have investigated LCD and ketone bodies so far, including remarkable weight reduction by LCD in 2699 cases, improvement of glucose level and Morbus (M) value, and changes of lipids and renal function [13-16]. Furthermore, we clarified the fraction ratio of KB (3-OHBA and Acetoacetate), and extremely elevated KB in fetus, placenta, newborn and mother blood, indicating that KB would have important role of generating energy [13-17].

Concerning diabetic treatment, systematic review in 2012 [18], comment for no one-size-fits-all in 2013 [19] and standard medical care in diabetes in 2015 [20] were valuable. From now, the new era would come to everyone with adequate management of LCD and KB for health [21].

As described above, the study of LCD and KB has been developed and contributed for diabetic research and clinical practice. In other words, new era has come for everyone leading to healthy life in the anti-aging perspective.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Journals

Article Usage

  • Total views: 215
  • [From(publication date):
    December-2017 - May 23, 2018]
  • Breakdown by view type
  • HTML page views : 180
  • PDF downloads : 35
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7