Perivascular Adipose Tissue can be Considered a Risk Factor forAtherosclerosis?
Leonardo Roever1*, Elmiro Santos Resende1 and Antonio Carlos Palandri Chagas2,3
1Department of Clinical Research, Federal University of Uberlandia, Brazil
2Heart Institute (InCor), HCFMUSP- University of Sao Paulo Medical School, Sao Paulo, Brazil
3Faculty of Medicine ABC, Santo Andre, Brazil
- *Corresponding Author:
- Leonardo Roever
Department of Clinical Research, Av. Para 1720
- Bairro Umuarama Uberlandia - MG - CEP 38400-902, Brazil
E-mail: [email protected] hotmail.com
Received Date: October 01, 2015 Accepted Date: May 02, 2016 Published Date: May 08, 2016
Citation: Roever L, Resende ES, Chagas ACP (2016) Perivascular Adipose Tissue can be Considered a Risk Factor for Atherosclerosis?. Atheroscler open access 1:e104. doi: 10.4172/asoa.1000e104
Copyright: © 2016 Roever L et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Perivascular adipose tissue (PVAT) is an ectopic deposition of adipose tissue surrounding the vasculature and your influence on the vasculature changes with increasing adiposity. PVAT involves coronary arteries, aorta, mesenteric, and small arteries in the body, and its likely function differs in each of these anatomical regions [1-4].
PVAT secretes a wide variety of adipocytokines and other substances, including hormones, cytokines, chemokines, oxygen radicals, angiotensinogen, leptin, resistin and fatty acids . The rate of secretion of various adipocytokines varies in different places in the vascular tree, adipocytokines as TNF-α, IL-6 and others. Adiponectin can affect insulin sensitivity, inflammatory responses, hemostasis, appetite and atherosclerosis [6-10]. The factors secreted by PVAT that act in the regulation of vascular function are presented in Table 1.
PVAT is related to the vascular contractility, endothelial dysfunction, neointima formation, arterial stiffness, aneurysm formation, and produce substances that can interfere in the process of atherosclerosis and contribute to the pathogenesis of type 2 diabetes and cardiovascular diseases [11-16].
An understanding of the pathophysiology of PVAT and its potential role in cardiovascular morbidity and mortality can be significant in preventing and treating of atherosclerosis.
- Fitzgibbons TP, Czech MP (2014) Epicardial and Perivascular Adipose Tissues and Their Influence on Cardiovascular Disease: Basic Mechanisms and Clinical Associations. J Am Heart Assoc 3: e000582.
- Lastra G, Manrique C (2015) Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease. HormMolBiolClinInvestig 22: 19-26.
- Britton KA, Pedley A, Massaro JM, Corsini EM, Murabito JM, et al. (2012) Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study. J Am Heart Assoc 1: e004200.
- Houben AJ, Eringa EC, Jonk AM, Serne EH, Smulders YM, et al. (2012) Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease. CurrCardiovasc Risk Rep 6: 80-90.
- Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, et al. (2003) Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108: 2460-2466.
- Lu C, Su LY, Lee RM, Gao YJ (2010) Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: the role of adipocyte-derived angiotensin II. Eur J Pharmacol 634: 107-112.
- Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, et al. (2009) Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 119:1661-1670.
- Chatterjee TK, Stoll LL, Denning GM, Harrelson A, Blomkalns AL, et al. (2009) Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding. Circ Res 104: 541-549.
- Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772-783.
- Padilla J, Vieira-Potter VJ, Jia G, Sowers JR (2015) Role of Perivascular Adipose Tissue on Vascular Reactive Oxygen Species in Type 2 Diabetes: A Give-and-Take Relationship. Diabetes 6: 1904-1906.
- Miao CY, Li ZY (2012) The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br J Pharmacol 165: 643-658.
- Villacorta L, Chang L (2015) The role of perivascular adipose tissue in vasoconstriction, arterial stiffness, and aneurysm. HormMolBiolClinInvestig 21: 137-147.
- Britton KA, Fox CS (2011) Perivascular adipose tissue and vascular disease. ClinLipidol 6: 79-91.
- Payne GA, Kohr MC, Tune JD (2012) Epicardial perivascular adipose tissue as a therapeutic target in obesity-related coronary artery disease. Br J Pharmacol 165: 659-669.
- Brown NK, Zhou Z, Zhang J, Zeng R, Wu J, et al. (2014) Perivascular Adipose Tissue in Vascular Function and Disease: A Review of Current Research and Animal Models. ArteriosclerThrombVascBiol 34: 1621-1630.
- Owen MK, Noblet JN, Sassoon DJ, Conteh AM , Goodwill AG, et al. (2014) Perivascular Adipose Tissue and Coronary Vascular Disease. ArteriosclerThrombVascBiol 34: 1643-1649.