Pharmacological Properties of Mentha Species
Received Date: Dec 20, 2017 / Accepted Date: Jan 10, 2018 / Published Date: Jan 11, 2018
People have been using plants in treating various diseases and obtaining successful results since old ages. Most of these plants have become natural medicines as a result of coincidences or curious practices. Different treatments by using different plants have been carried out and proven to be healing and plants have become significant and popular among people in a short period. Mentha species, which have a significant place in alternative medicine, has pharmacological effect. In this research, based on previous study results, the effects of Mentha species, which has been used for various purposes including medical, nourishing aims and as spice, are analyzed and presented.
Keywords: Mentha; Pharmacology; Alternative medicine; Medicine; Plant
It is assumed that there are approximately 1 million different plant species on earth while almost 500 thousand have been determined until today. On the other hand, the number of species that could be determined has been increasing every day. According to the report of World Health Organization (WHO), based on various publishing about codex of 91 countries (pharmacopeia) and medicinal plants, the number of plants used in medicine is around 20 thousand .
Phytotherapy has become a discipline after plants that have been used in traditional folk medicine is filtered scientifically and re-evaluated; the word itself means treatment through plants. The discipline has been developing and gaining importance every day. According to the data presented by World Health Organization (WHO), 80% of people in developing countries have been using phytotherapy methods and 3.3 billion people have been using medicinal plants for medicinal purposes .
25% of active substances in medicines that are produced pharmacologically in modern respect are obtained from plants. On the other hand, active substances of most of the artificially produced medicines are structurally similar to the chemicals which were firstly isolated from plants. Demand for plants with which medicines are produced have been increasing in both developing and developed countries as they are affordable, they don’t have any side effects, they have low toxic effect and they are produced naturally .
Properties of Mentha (L.)
An important part of the useful plants that have been known since the past and have never lost their significance to date are the plants found in the Lamiaceae family. In this study, Mentha species were selected as a subject from the Lamiaceae family (Figure 1). Mentha is a perennial plant growing in humid environment while there are some exceptional annual Mentha plants. They have creeping rhizomes. They have simple, characteristic leaves with beautiful scent. Flowers of the plant are either hermaphrodite or they are on the pistil or on a different plant. Calyx is actinomorphic or sub-bilabial, tubular or campanulate; the plant is 10-13 vascular, 5 sub-equal or unequal teeth. Coralla weakly 2-lipped, sub-equal lobe, upper lobe is wider, generally emarginated and shorter than tubecalyx. It has 4 stamens and rises from below the labium outwardly. Fruits are small, smooth, nutlets smooth, foveolate or reticulate .
Many plants contain a wide variety of chemical substances that have significant biological effects on humans. Whether used for what purpose, plants give the nature struggle for survival a number of things that they already produce in their own structures. Plants also have living spaces that grow and develop, feed and build up the next generation like other creatures. In these areas they are subjected to many biotic or abiotic processes while living their lives. The plants protect themselves from these factors in other ways because they have no chance of getting away or escaping. In order to protect themselves, plants produce a number of substances under the name of secondary minerals during photosynthesis. These secondary products are very important ingredients for plants in terms of maintaining harmony, protection, defence and continuing their generations [5-8].
In essential oils of Mentha species, there are basic components such as menthol (33-60%), menthone (15-32%), isomenthone (2-8%), 1.8 sineol (eucalyptols) (5-13%), menthyl acetate (2-11%) menthofuran (1- 7%), limonene (1-7%), β-myrcene (0.1-1.7%), β-caryophyllene (2-4%), pulegone (0.5-1.6%) carvone (1%) [9,10]. On the other hand, it is stated that there are some compounds in Mentha species such as neomenthol, carvomenthone, p-cymene, aromadendrene, phellandrene, pipertone, pinene, carvacrol, α-pinene, α-phellandrene and thujone [11-13].
Results And Discussion
In studies on Mentha species, different methods are practiced, different dissolvent and essential oils of plants are used and various pharmacologic effects are determined. In the related studies on species, it is found that Mentha species have significant effects such as analgesic, anti-inflammatory, antipyretic, DNA damage protecting activity, antioxidant, anti-androgenic, antimicrobial, cytotoxic, antiviral, anticancer, antiemetic, antibacterial, antiallergic, antiparazitic, sedative, anti-chlamydial, radioprotection, anti-cholinesterase, hepatoprotective, antispasmodic, acute toxicity effect, anti-mutagenic, cardiovascular effects and anti-tumour effects (Table 1) [14-82].
|Mentha plants||Pharmacological effect||Extraction|
|Mentha spicata||Analgesic [14,18], Anti-inflammatory [18,28], Antipyretic , DNA damage protecting activity [25,27], Antioxidant [21,59], Anti-androgenic , Antimicrobial [42,47,74], Cytotoxic [42,52], Antiviral , Anticancer , Antiemetic ||Essential oils, Methanol, Diethyl ether, Ethyl acetate, n-butanol, Ethanol, Hexane, Chloroform, Aqueous, Water|
|M. spicata var. crispa||Antibacterial , Anti-allergic , Antioxidant ||Essential oils, Methanol, Water-soluble|
|Mentha × piperita||Analgesic [15,19,24,43], Antimicrobial [20,37,42,47,74], Antioxidant [20,45,53,57], Antibacterial [22,53], Antiparazitic , Sedative , Antichlamydial , Cytotoxic [42,54,57], Anti-inflammatory [43,57], Antiviral , Anticancer [51,54], Antiemetic , Radioprotection ||Essential oils, Aqueous extracts, Ethanol, Hexane, Chloroform, Methanol, Water-soluble, Petroleum ether, Benzene, Ethyl acetate|
|M. arvensis||Analgesic , Antimicrobial [16,42], Antioxidant , Antibacterial , Sedative , Anti-inflammatory [38,75] Cytotoxic , Anticancer , Hepatoprotective , Anti-allergic ||Ethanol, Essential oils, Methanol, Aqueous, Chloroform|
|M. arvensis var. japanensis||Antioxidant ||Water-soluble|
|M. cordifolia||Analgesic , Antioxidant ||Ethanol, Aqueous|
|M. aquatica||Antimicrobial , Antioxidant [21,44,45], Anticholinesterase , Anti-inflammatory ||Essential oils, Ether, Chloroform, Ethyl acetate and n-BuOH, hydroalcoholic|
|M. longifolia||Antimicrobial [20,32,42,66,69,78], Antioxidant [20,32,63,66,67,68,78], Cytotoxic [32,42,50], Anticancer , Hepatoprotective , Antispasmodic , Antibacterial [67,70], Acute Toxicity Effect , Antiviral ||Essential oils, Methanol, Aqueous, Ethanol, Hydroalcoholic|
|M. longifolia subsp. longifolia||Antimutagenic , Antioxidant [65,71], Antimicrobial [65,71],||Ethanol, Methanol|
|M. mozaffarianii||Analgesic , Antimicrobial ||Essential oils|
|M. pulegium||Antiparazitic , Antimicrobial [29,39,40], Antioxidant [40,81], Antispasmodic , Antimutagenic ||Essential oils, Hot water, Cold water, Ethanol, Hexane, Methanol, Dichloromethanol|
|M. viridis||Analgesic , Antiparazitic , Anticancer , Antioxidant , Antimicrobial ||Methanol, Aqueous|
|M. suaveolens||Cardiovascular Effects , Antibacterial , Analgesic , Anti-inflammatory , Antiviral ||Methanol, Dichloromethanol, Ethanol, Hexane, Essential oils|
|M. australis||Antioxidant ||Methanol|
|M. rotundifolia||Antibacterial , Antioxidant , Antimicrobial ||Essential oils|
|M. haplocalyx||Antioxidant , Anti-inflammatory , Anti-allergic ||Water-soluble, Ethanol|
|Mentha × dalmatica||Antioxidant ||Water-soluble|
|Mentha × verticillata||Antioxidant ||Water-soluble|
|Mentha ×villosa||Cytotoxic , Antitumour ||Essential oils|
|M. canadensis||Antioxidant ||Methanol|
|M. dumetorum||Antimicrobial ||Essential oils|
Table 1: Pharmacological effects of Mentha species.
Plants have been used by people in alternative medicine for different purposes since old ages. Nutraceutical and functional foods help protect against a chronic illness, reducing illness effects (82). It has been reported that various pharmacological effects of Mentha species, one of the nutraceutical and functional foods, are reported. In this study, effects of Mentha species are stated. In this context, it is believed that Mentha species can be used in the treatment of many different diseases. After determining phytochemical content of Mentha species, they can be isolated and used in designing modern medicines. On the other hand, side effects of medicines that have been used currently can be eliminated. As a result, besides the fact that the use of Mentha species is quite significant, it is thought that the plant has an important place in the production of pharmaceutical products.
- Baytop T (1999) Türkiye’de Bitkiler ile Tedavi (Geçmiste ve Bugün). Nobel Tıp Kitap Evleri 2. Baskı.
- Çelik E, Çelik GY (2007) Bitki Uçucu Yağlarının Antimikrobiyal Özellikleri. Orlab On-Line Mikrobiyoloji Dergisi 5: 1-6.
- Sekar S, Kandavel D (2010) Interaction of plant growth promoting rhizobacteria (PGPR) and endophytes with medicinal plants- New avenues for phytochemicals. J Phytology 2: 91-100.
- Harley RM, Davis PH(Ed) (1982) Mentha L. İn: Flora of Turkey and The East Aegean Islands. Volume 11. England: Edinburgh University Press. pp: 384-385.
- Sevindik M, Akgül H, Akata I, Selamoglu Z (2017) Geastrum pectinatum as an Alternative Antioxidant Source with some Biochemical Analysis. Medical Mycology: Open Access 3: 25.
- Pasdaran A, Delazar A, Ayatollahi SA, Pasdaran A (2017) Chemical composition and biological activities of methanolic extract of Scrophularia oxysepala Boiss. Iranian Journal of Pharmaceutical Research: IJPR 16: 338.
- Albayrak S, Aksoy A, Yurtseven L, Yaşar A (2014) A comparative study on phenolic components and biological activity of some Senecio species in Turkey. J Pharm Pharmacol 66: 1631-1640.
- Pehlivan M, Akgül H, Yayla F (2013) The some nutrient and trace elements content of wild plants using as ethno botanical and grown in the Gaziantep region. J Appl Pharm Sci 3: 143-145.
- Pittler MH, Ernst E (1998) Peppermint oil for irritable bowel syndrome: A critical review and metaanalysis. Am J Gastroenterol 93: 1131-1135.
- Peixoto ITA, Furletti VF, Anival PC, Duarte MCT, Höfling JF (2010) Potential pharmacological and toxicological basis of the essential oil from Mentha spp. Revista de Ciências Farmacêuticas Básica e Aplicada 30: 235-239.
- Satyavati GV, Gupta AK, Tandon N (1987) Medicinal Plants of India. New Delhi, India: Indian Council of Medical Research 230-239.
- CSIR (1972) Wealth of India, Raw Materials. New Delhi, India: Council of Scientific and Industrial Research 43: 337-346.
- Thawkar BS, Jawarkar AG, Kalamkar PV, Pawar KP, Kale MK (2016) Phytochemical and pharmacological review of Mentha arvensis. Int J Green Pharm 10: 76.
- Mahboubi M (2017) Mentha spicata as natural analgesia for treatment of pain in osteoarthritis patients. Complement Ther Clin Pract 26: 1-4.
- Taher YA (2012) Antinociceptive activity of Mentha piperita leaf aqueous extract in mice. Libyan J Med 7: 16205.
- Biswas NN, Saha S, Ali MK (2014) Antioxidant, antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Mentha arvensis L. Asian Pac J Trop Biomed 4: 792-797.
- Villasenor IM, Sanchez AC (2009) Menthalactone, a new analgesic from Mentha cordifolia Opiz. leaves. Z Naturforsch C 64: 809-812.
- Yousuf PMH, Noba NY, Shohel M, Bhattacherjee R, Das BK (2013) Analgesic, Anti-Inflammatory and Antipyretic Effect of Mentha spicata (Spearmint). Br J Pharm Res 3: 854-864.
- Saleh ANA (2010) The analgesic activity of Mentha piperita (MP) leaves extract. Iraqi J Vet Med 34: 73-78.
- Mimica-Dukic N, Božin B, Soković M, Mihajlović B, Matavulj M (2003) Antimicrobial and antioxidant activities of three Mentha species essential oils. Planta Med 69: 413-419.
- Ferhat M, Erol E, Beladjila KA, Çetintaş Y, Duru ME, et al. (2017) Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica. Pharmaceutical Biology 55: 324-329.
- Horváth P, Koščová J (2017) In vitro Antibacterial Activity of Mentha Essential Oils Against Staphylococcus aureus. Folia Veterinaria 61: 71-77.
- Sam-Dahri H, Mousavi Z, Naderi N, Asgarpanah J (2016) Chemical composition and analgesic activity of the essential oil of Mentha mozaffarianii jamzad leaves. Bulgarian Chemical Communications 48: 641-645.
- Di Stasi LC, Oliveira GP, Carvalhaes MA, Queiroz-Junior M, Tien OS, et al. (2002) Medicinal plants popularly used in the Brazilian tropical Atlantic forest. Fitoterapia 73: 69-91.
- Kumar A, Chattopadhyay S (2007) DNA damage protecting activity and antioxidant potential of pudina extract. Food Chem 100: 1377-1384.
- Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, et al. (2007) Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother Res 21: 444-447.
- Arumugam P, Ramesh A (2009) Protective effects of solvent fractions of Mentha spicata (L.) leaves evaluated on 4-nitroquinoline-1-oxide induced chromosome damage and apoptosis in mouse bone marrow cells. Genet Mol Biol 32: 847-852.
- Arumugam P, Priya NG, Subathra M, Ramesh A (2008) Anti-inflammatory activity of four solvent fractions of ethanol extract of Mentha spicata L. investigated on acute and chronic inflammation induced rats. Environ Toxicol Pharmacol 26: 92-95.
- Mahboubi M, Haghi G (2008) Antimicrobial activity and chemical composition of Mentha pulegium L. essential oil. J Ethnopharmacol 119: 325-327.
- Bello R, Calatayud S, Beltran B, Primo‐Yúfera E, Esplugues J (2001) Cardiovascular effects of the methanol and dichloromethanol extracts from Mentha suaveolens Ehrh. Phytother Res15: 447-448.
- Sutour S, Bradesi P, de Rocca‐Serra D, Casanova J, Tomi F (2008) Chemical composition and antibacterial activity of the essential oil from Mentha suaveolens ssp. insularis (Req.) Greuter. Flavour Fragr J 23: 107-114.
- Mikaili P, Mojaverrostami S, Moloudizargari M, Aghajanshakeri S (2013) Pharmacological and therapeutic effects of Mentha longifolia L. and its main constituent, menthol. Anc Sci Life 33: 131.
- Kapp K, Hakala E, Orav A, Pohjala L, Vuorela P, et al. (2013) Commercial peppermint (Mentha × piperita L.) teas: Antichlamydial effect and polyphenolic composition. Food Res Int 53: 758-766.
- Tang KS, Konczak I, Zhao J (2016) Identification and quantification of phenolics in Australian native mint (Mentha australis R. Br.). Food Chem 192: 698-705
- Moreno L, Bello R, Primo YE, Esplugues J (2002) Pharmacological properties of the methanol extract from Mentha suaveolens Ehrh. Phytotherapy Research 16:10-13.
- Yamamura S, Ozawa K, Ohtani K, Kasai R, Yamasaki K (1998) Antihistaminic flavones and aliphatic glycosides from Mentha spicata. Phytochemistry 48: 131-136.
- Verma A, Joshi P, Arya A (2013) Screening of eight plant extracts for their antimicrobial properties. Int J Curr Microbiol App Sci 2: 315-320.
- Verma SM, Arora H, Dubey R (2003) Anti-inflammatory and sedative-hypnotic activity of the methanolic extract of the leaves of Mentha arvensis. Ancient Science of Life 23: 95.
- Ait-Ouazzou A, Lorán S, Arakrak A, Laglaoui A, Rota C, et al. (2012) Evaluation of the chemical composition and antimicrobial activity of Mentha pulegium, Juniperus phoenicea, and Cyperus longus essential oils from Morocco. Food Research International 45: 313-319.
- Teixeira B, Marques A, Ramos C, Batista I, Serrano C, et al. (2012) European pennyroyal (Mentha pulegium) from Portugal: Chemical composition of essential oil and antioxidant and antimicrobial properties of extracts and essential oil. Industrial Crops and Products 36: 81-87.
- Derwich E, Benziane Z, Boukir A (2010) Antibacterial activity and chemical composition of the leaf essential oil of Mentha rotundifolia from Morocco. Electronic Journal of Environmental, Agricultural & Food Chemistry 9: 1074-1084.
- Hussain AI, Anwar F, Nigam PS, Ashraf M, Gilani AH (2010) Seasonal variation in content, chemical composition and antimicrobial and cytotoxic activities of essential oils from four Mentha species. Journal of the Science of Food and Agriculture 90: 1827-1836.
- Belemkar S, Thakre SA, Pata MK (2013) Evaluation of anti-inflammatory and analgesic activities of methanolic extract of Adhatoda vasika Nees and Mentha piperita Linn. Inventi Rapid: Ethnopharmacology 2: 827.
- Conforti F, Sosa S, Marrelli M, Menichini F, Statti GA, et al. (2008) In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. Journal of Ethnopharmacology 116: 144-151.
- Dorman HD, Koşar M, Kahlos K, Holm Y, Hiltunen R (2003) Antioxidant properties and composition of aqueous extracts from Mentha species, hybrids, varieties, and cultivars. Journal of Agricultural and Food Chemistry 51: 4563-4569.
- Civitelli L, Panella S, Marcocci ME, De Petris A, Garzoli S, et al. (2014) In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide. Phytomedicine 21: 857-865.
- Orhan IE, Özçelik B, Kartal M, Kan Y (2012) Antimicrobial and antiviral effects of essential oils from selected Umbelliferae and Labiatae plants and individual essential oil components. Turkish Journal of Biology 36: 239-246.
- Amaral RG, Fonseca CS, Silva TKM, Andrade LN, França ME, et al. (2015) Evaluation of the cytotoxic and antitumour effects of the essential oil from Mentha × villosa and its main compound, rotundifolone. Journal of Pharmacy and Pharmacology 67: 1100-1106.
- Sharma V, Hussain S, Gupta M, Saxena AK (2014) In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells. Indian J Biochem Biophys 51: 416-419.
- Al-Ali KH, El-Beshbishy HA, El-Badry AA, Alkhalaf M (2013) Cytotoxic activity of methanolic extract of Mentha longifolia and Ocimum basilicum against human brast cancer. Pakistan Journal of Biological Sciences: PJBS 16: 1744-1750.
- Abirami SG, Nirmala P (2014) A comparative-in vitro study of anticancer effect of Mentha piperita, ocimum basilicum and coleus aromaticus against human laryngeal epidermoid carcinoma (HEP-2) cell lines. Journal of Medicinal Plants 2: 6-9.
- Hajighasemi F, Hashemi V, Khoshzaban F (2011) Cytotoxic effect of Mentha spicata aqueous extract on cancerous cell lines in vitro. Journal of Medicinal Plants Research 5: 5142-5147.
- Singh R, Shushni MA, Belkheir A (2015) Antibacterial and antioxidant activities of Mentha piperita L. Arabian Journal of Chemistry 8: 322-328.
- Jain D, Pathak N, Khan S, Raghuram GV, Bhargava A, et al. (2011) Evaluation of cytotoxicity and anticarcinogenic potential of Mentha leaf extracts. International Journal of Toxicology 30: 225-236.
- Shan B, Cai YZ, Sun M, Corke H (2005) Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem 53: 7749-7759.
- Tayarani-Najaran Z, Talasaz-Firoozi E, Nasiri R, Jalali N, Nassanzadeh MK (2013) Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting. Ecancermedicalscience 7: 290.
- Sun Z, Wang H, Wang J, Zhou L, Yang P (2014) Chemical composition and anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita grown in China. PloS one 9: e114767.
- Samarth RM, Kumar A (2003) Radioprotection of Swiss albino mice by plant extract Mentha piperita (Linn.). J Radiat Res 44: 101-109.
- Patil K, Mall A (2012) Hepatoprotective activity of Mentha arvensis Linn. leaves against CCL4 induced liver damage in rats. Asian Pac J Trop Dis 2: 223-226.
- Mimica-Dukic N, Popovic M, Jakovljevic V, Szabo A, Gašic O (1999) Pharmacological studies of Mentha longifolia phenolic extracts. II. Hepatoprotective activity. Pharm Biol 37: 221-224.
- Estrada-Soto S, González-Maldonado D, Castillo-España P, Aguirre-Crespo F, Sánchez-Salgado JC (2010) Spasmolytic effect of Mentha pulegium L. involves ionic flux regulation in rat ileum strips. J Smooth Muscle Res 246: 107-117.
- Naseri MK, Naseri ZG, Mohammadian M, Birgani MO (2008) Ileal relaxation induced by Mentha longifolia (L.) leaf extract in rat. Pak J Biol Sci 11: 1594-1599.
- Malik B, Sharma NR, Soni G (2013) Influence of agro-climatic conditions on antioxidant potential of Mentha species. Journal of Pharmacy Research 7: 427-432.
- Orhan F, Barış Ö, Yanmış D, Bal T, Güvenalp Z, Güllüce M (2012) Isolation of some luteolin derivatives from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potencies. Food Chem 135: 764-769.
- Sevindik M, Akgul H, Pehlivan M, Selamoglu Z (2017) Determination of therapeutic potential of Mentha longifolia ssp. longifolia. Fresen Environ Bull 26: 4757-4763
- Niksic H, Besovic EK, Makarevic E, Duric K (2012) Chemical composition, antimicrobial and antioxidant properties of Mentha longifolia (L.) Huds. essential oil. J Health Sci 2: 192-200
- Janifer RX, Bajpjpai PK, Phani KG, Pal MM, Jitendra K, et al. (2010) Determination of total phenols, free radical scavenging and antibacterial activities of Mentha longifolia Linn. Hudson from the Cold Desert, Ladakh, India. Phcog J 2: 470-475.
- Motamed SM, Naghibi F (2010) Antioxidant activity of some edible plants of the Turkmen Sahra region in northern Iran. Food Chemistry 119: 1637-1642.
- Al-Bayati FA (2009) Isolation and identification of antimicrobial compound from Mentha longifolia L. leaves grown wild in Iraq. Ann Clin Microbiol Antimicrob 8: 20.
- Akroum S, Bendjeddou D, Satta D, Lalaoui K (2009) Antibacterial activity and acute toxicity effect of flavonoids extracted from Mentha longifolia. American-Eurasian Journal of Scientific Research 4 (2): 93-96.
- Gulluce M, Sahin F, Sokmen M, Ozer H, Daferera D, et al. (2007) Antimicrobial and antioxidant properties of the essential oils and methanol extract from Mentha longifolia L. ssp. longifolia. Food Chemistry 103: 1449-1456.
- Khattak S, Rehman SU, Khan T, Shah HU, Shad AA, Ahmad M (2004) In vitro screening for biological and pharmacological effects of indigenous medicinal plants, Mentha longifolia and Aloe vera. J Chem Soc Pakistan 26: 248-251.
- Amzazi S, Ghoulami S, Bakri Y, Idrissi AI, Fkih-Tétouani S, et al. (2003) Human immunodeficiency virus type 1 inhibitory activity of Mentha longifolia. Therapie 58: 531-534.
- Yanar Y, Belgüzar S, Telci I (2016) Origanum spp., Mentha spp. ve Lippia sp. Türlerine Ait Uçucu Yağların Clavibacter michiganensis subsp. michiganensis ve Botrytis cinerea’ya Karşı Antimikrobiyal Etkisi. Turkish Journal of Weed Science 19: 18-25.
- Malik F, Hussain S, Sadiq A, Parveen G, Wajid A, et al. (2012) Phyto-chemical analysis, anti-allergic and anti-inflammatory activity of Mentha arvensis in animals. Afr J Pharm Pharmacol 6: 613-619.
- Pakdeechote P, Prachaney P, Berkban W, Kukongviriyapan U, Kukongviriyapan V, et al. (2014) Vascular and antioxidant effects of an aqueous Mentha cordifolia extract in experimental NG-nitro-L-arginine methyl ester-induced hypertension. Z Naturforsch C 69: 35-45.
- Teymouri M, Alizadeh A (2017) Chemical composition and antimicrobial activity of the essential oil of Mentha mozaffarianii Jamzad growing wild and cultivated in Iran. Nat Prod Res 28: 1-4.
- Mkaddem M, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, et al. (2009) Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils. J Food Sci 74: 690
- Riahi L, Elferchichi M, Ghazghazi H, Jebali J, Ziadi S, et al. (2013) Phytochemistry, antioxidant and antimicrobial activities of the essential oils of Mentha rotundifolia L. in Tunisia. Ind Crops Prod 49: 883-889.
- Lee MY, Lee JA, Seo CS, Ha H, Lee NH, et al. (2011) Protective effects of Mentha haplocalyx ethanol extract (MH) in a mouse model of allergic asthma. Phytother Res 2: 863-869.
- Yumrutas O, Saygıdeger SD (2012) Determination of antioxidant and antimutagenic activities of Phlomis armeniaca and Mentha pulegium. J Appl Pharm Sci 2012: 36-40.
- Scicchitano P, Cameli M, Maiello M, Modesti PA, Muiesan ML, et al. (2014) Nutraceuticals and dyslipidaemia: Beyond the common therapeutics. Journal of Functional Foods 6: 11-32.
Citation: Sevindik M (2018) Pharmacological Properties of Mentha Species. J Tradit Med Clin Natur 7: 259. DOI: 10.4172/2573-4555.1000259
Copyright: © 2018 Sevindik M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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