alexa Thermal Analysis Methods in Pharmaceutical Quality Control
ISSN: 2329-9053
Journal of Molecular Pharmaceutics & Organic Process Research
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  • Editorial   
  • J Mol Pharm Org Process Res 2015, Vol 3(1): e121
  • DOI: 10.4172/2329-9053.1000e121

Thermal Analysis Methods in Pharmaceutical Quality Control

Monajjemzadeh F,1,2* and Ghaderi F3
1Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Student research committee of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Monajjemzadeh F,, Associate Professor, Department of Pharmaceutical and Food Control, Tabriz University of Medical Sciences, Tabriz, Zip Code: 5166414766, Iran, Tel: +9841133392606, Fax: +9841133344798, Email: [email protected]

Received Date: Feb 19, 2015 / Accepted Date: Feb 20, 2015 / Published Date: Feb 25, 2015

Thermal analysis is defined as a group of physical-chemical methods which the properties of studied material are measured as a function of temperature or time while the sample is placed under a controlled temperature program. The program may include heating or cooling (dynamic), or fixed temperature (isothermal), or a combination of these methods [1,2]. Different multi-component techniques including thermogravimetry, differential thermal analysis, differential scanning calorimetry and thermo-microscopy are available instrumentally. Nowadays, these methods has gained significant attention in both quality control and functional research on Industries such as polymers, pharmaceuticals, metals and alloys [3,4]. Thermogravimetry (TG) or Thermogravimetric analysis (TGA) is a fundamental laboratory instruments applied for investigation of the material properties in various fields such as pharmaceutical, environmental, food and petrochemical applications [5]. TGA is a technique in which the amount of weight change of a substance, is monitored either as a function of controlled temperature, or isothermally as a function of time, in an atmosphere of N2, He, air, other gas, or in vacuum [6]. The differential thermal analysis (DTA) is common thermal analysis method in which an analyte and an inert reference are heating at a certain heating rate while any temperature change is recorded. DTA is a popular tool used to characterize pharmaceuticals, foods, biologicals, organic and inorganic chemicals and briefly applied to measure endothermic and exothermic transitions as a function of temperature [7,8]. Differential scanning calorimetry or DSC is a popular thermoanalytical technique ranging from the pharmaceutical science to applied research. DSC monitors the difference in the amount of required heat to increase the temperature of a sample and reference (which should have an acceptable heat capacity in the range of scanned temperatures) as a function of temperature [9,10].

Thermo microscope or hot stage microscope (HSM) is a microscope coupled with a hot stage accessory with excellent heating and cooling systems ranging from -200°C to 500°C. For study the visual changes a color camera is connected to the microscope. This method records the surface temperature and thermal conductivity of an interface [11-13].

In pharmaceutical control all mentioned thermal techniques are of significant importance. The drug substance purity, polymorphism, stability can be easily evaluated using thermal analysis [10,14-17]. In the case of pharmaceutical excipients, the purity, glass transition temperature of polymeric materials and drug-excipient compatibility is simply monitored using these methods [18,19]. Recently kinetic analysis has been performed based on different thermal techniques such as DSC and TGA, and various models have been proposed in order to analyze the Arrhenius kinetic parameters [20-22].

References

Citation: Monajjemzadeh F, Ghaderi F (2015) Thermal Analysis Methods in Pharmaceutical Quality Control. J Mol Pharm Org Process Res 3: e121. Doi: 10.4172/2329-9053.1000e121

Copyright: ©2015 Monajjemzadeh F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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