alexa Otolaryngology Research: A New frontier in Head and Neck Cancer Genomics
ISSN: 2161-119X
Otolaryngology: Open Access

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Editorial   
  • otolaryngol 2011, Vol 1(1): 102e
  • DOI: 10.4172/2161-119X.1000102e

Otolaryngology Research: A New frontier in Head and Neck Cancer Genomics

Sufi Mary Thomas*
Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, USA
*Corresponding Author: Sufi Mary Thomas, 200 Lothrop Street, W947 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15213, USA, Email: [email protected]

Received Date: Aug 01, 2011 / Accepted Date: Aug 02, 2011 / Published Date: Aug 04, 2011

Abstract

Current research on diseases of the ear, nose, throat and related structures of the head and neck has experienced significant strides in areas including cancer, otology, rhinology and laryngology. Molecular diagnostics and advanced imaging modalities including positron emission tomography have facilitated diagnosis and patient outcomes. Collaborations between physicians and laboratory researchers working to identify key clinical issues and translating the biological insights into novel therapeutic approaches are crucial to significant progress in the field. Tumors of the head and neck are the 6th most common cancer worldwide with high 5-year mortality rates. The most common type of head and neck cancer is squamous cell carcinoma (SCC). Although the incidence of the disease has been reducing possibly due to an increased awareness of the carcinogenic effects of tobacco, there has been a steady rise in human papilloma virus (HPV) associated oropharyngeal carcinoma. Mutations in the tumor suppressor gene p53 is observed in the majority of head and neck SCC patients [1]. Recently, two reports by independent teams comprising of an amalgamation of clinicians and basic scientists elucidated the whole-exome (protein coding genes) mutational profile of head and neck tumor-normal pairs [2,3]. In addition to p53 mutations, both groups reported mutations in genes involved in the differentiation pathway involving NOTCH 1. Interestingly, tobacco exposure increased the number mutations compared to tumors with no tobacco exposure [3]. In addition, HPV expressing tumors had fewer mutations than HPV positive tumors. Further determinations of the function of these mutations in tumor growth and dissemination are necessary. These studies set the stage for further work in the areas of target identification and therapeutics pertaining to personalized medicine.

Current research on diseases of the ear, nose, throat and related structures of the head and neck has experienced significant strides in areas including cancer, otology, rhinology and laryngology. Molecular diagnostics and advanced imaging modalities including positron emission tomography have facilitated diagnosis and patient outcomes. Collaborations between physicians and laboratory researchers working to identify key clinical issues and translating the biological insights into novel therapeutic approaches are crucial to significant progress in the field.

Tumors of the head and neck are the 6th most common cancer worldwide with high 5-year mortality rates. The most common type of head and neck cancer is squamous cell carcinoma (SCC). Although the incidence of the disease has been reducing possibly due to an increased awareness of the carcinogenic effects of tobacco, there has been a steady rise in human papilloma virus (HPV) associated oropharyngeal carcinoma. Mutations in the tumor suppressor gene p53 is observed in the majority of head and neck SCC patients [1]. Recently, two reports by independent teams comprising of an amalgamation of clinicians and basic scientists elucidated the whole-exome (protein coding genes) mutational profile of head and neck tumor-normal pairs [2,3]. In addition to p53 mutations, both groups reported mutations in genes involved in the differentiation pathway involving NOTCH 1. Interestingly, tobacco exposure increased the number mutations compared to tumors with no tobacco exposure [3]. In addition, HPV expressing tumors had fewer mutations than HPV positive tumors. Further determinations of the function of these mutations in tumor growth and dissemination are necessary. These studies set the stage for further work in the areas of target identification and therapeutics pertaining to personalized medicine.

References

Citation: Thomas SM (2011) Otolaryngology Research: A New frontier in Head and Neck Cancer Genomics. Otolaryngology 1:102e. Doi: 10.4172/2161-119X.1000102e

Copyright: © 2011 Thomas SM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 12122
  • [From(publication date): 8-2011 - Nov 17, 2019]
  • Breakdown by view type
  • HTML page views: 8281
  • PDF downloads: 3841
Share This Article
Top