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South Africa is the 25th-largest country in the world by land area, and with close to 53 million people, is the world's 24th-most populous nation. It is the southernmost country on the mainland of the Old World or the Eastern Hemisphere. South Africa is a multiethnic society encompassing a wide variety of cultures, languages, and religions. Its pluralistic makeup is reflected in the constitution's recognition of 11 official languages, which is among the highest number of any country in the world. Two of these languages are of European origin: Afrikaans developed from Dutch and serves as the first language of most white and coloured South Africans; English reflects the legacy of British colonialism, and is commonly used in public and commercial life, though it is fourth-ranked as a spoken first language.

Republic of South Africa is the southernmost sovereign state in Africa. It is bounded on the south by 2,798 kilometers of coastline of Southern Africa stretching along the South Atlantic and Indian Oceans, on the north by the neighboring countries of Namibia, Botswana and Zimbabwe, and on the east by Mozambique and Swaziland, and surrounding the kingdom of Lesotho.

South Africa has a mixed economy, the second largest in Africa after Nigeria. It also has a relatively high GDP per capita compared to other countries in Sub-Saharan Africa ($11,750 at PPP as of 2012). Despite this, South Africa is still burdened by a relatively high rate of poverty and unemployment, and is also ranked in the top 10 countries in the world for income inequality, measured by the Gini coefficient. Unlike most of the world's poor countries, South Africa does not have a thriving informal economy. Only 15% of South African jobs are in the informal sector, compared with around half in Brazil and India and nearly three-quarters in Indonesia. The OECD attributes this difference to South Africa's widespread welfare system. World Bank research shows that South Africa has one of the widest gaps between per capita GNP versus its Human Development Index ranking, with only Botswana showing a larger gap.

Several important scientific (list of pathology journal)and technological developments in patholgy have originated in South Africa. The first human-to-human heart transplant was performed by cardiac surgeon Christiaan Barnard at Groote Schuur Hospital in December 1967, Max Theiler developed a vaccine against yellow fever, Allan McLeod Cormack pioneered x-ray computed tomography, and Aaron Klug developed crystallographic electron microscopy techniques develop for the pathological diseases diagnosis. so many pathology laboratary (Clinical pathology) is open in South Africa to test the huge blood sample of the patients

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