alexa A Highly Sensitive LC-Ms/Ms Method for Determination of Desvenlafaxine in Rabbit Plasma and its Application to Rabbit Pharmacokinetic Study
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Research Article

A Highly Sensitive LC-Ms/Ms Method for Determination of Desvenlafaxine in Rabbit Plasma and its Application to Rabbit Pharmacokinetic Study

Shashidhar Reddy D1*, Prakash Rao2 and Devaraj VC1

1Department of Pharmacology, Bioneeds Preclinical Services, Bangalore, India

2Department of Pharmaceutics, Karnataka College of Pharmacy, Bangalore, India

*Corresponding Author:
Dr. Shashidhar Reddy.D
Research Scholar
Dept. of Pharmacology
Bioneeds Laboratory Animals & Preclinical Services
Bangalore: 562111, Karnataka, India
Tel: +91 8374093233, +91 8453336609
Fax: 914067204199
E-mail: [email protected], [email protected]

Received date: September 07, 2011; Accepted date: October 07, 2011; Published date: October 25, 2011

Citation: Reddy SD, Rao P, Devaraj VC (2011) A Highly Sensitive LC-Ms/Ms Method for Determination of Desvenlafaxine in Rabbit Plasma and its Application to Rabbit Pharmacokinetic Study. J Anal Bioanal Tech 2:125. doi: 10.4172/2155-9872.1000125

Copyright: © 2011 Reddy SD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A highly senstive and rapid LC-MS/MS method has been developed and validated for the estimation of desvenlafaxine in rabbit plasma. The chromatographic separation was performed with 0.2% formic acid: methanol at flow rate of 0.4 mL/min on Symmetry Shield RP18 column with a total run time of 3.0 min. TheMS/MS ion transitions monitored were 263.90? 58.10 for desvenlafaxine and 281.30--> 86.10 for IS (metaprolol). Method validation and pre-clinical sample analysis were performed as per FDA guide lines and the results met the acceptance crieteria. The lower limit of quantification achieved was 0.5 ng/mL and the linearity was observed from 0.5 to 1500 ng/mL. This novel method has been applied to pharmacokinetic study of desvenlafaxine in rabbits.

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