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A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal | OMICS International | Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Research Article

A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal

Sandra F Martins1-3, Ricardo Amorim1,2, Rui M Reis1,2, Céline Pinheiro1,2, Mesquita Rodrigues4, Fátima Baltazar1,2 and Adhemar Longatto Filho1,2,5*

1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

2ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal

3Surgery Department - Centro Hospitalar Trás-os-Montes e Alto Douro, Portugal

4Coloproctology Unit–Hospital Braga, Portugal

5Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of São Paulo, Brazil

*Corresponding Author:
Adhemar Longatto Filho
Life and Health Sciences Research Institute (ICVS)
School of Health Sciences, University of Minho, Braga, Portugal
Tel: + 351 253 604827
Fax: + 351 253 6048472

Received date: September 04, 2013; Accepted date: October 23, 2013; Published date: October 30, 2013

Citation: Martins SF, Amorim R, Reis RM, Pinheiro C, Rodrigues M, et al. (2013) A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital, Northern Portugal. J Gastroint Dig Syst 3:146. doi: 10.4172/2161-069X.1000146

Copyright: © 2013 Martins SF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Colorectal cancer (CRC) is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nonetheless, despite being a frequent cancer on which many epidemiological international studies have already been written, Portuguese epidemiological data are scarce and in particular there are very few specific data for Minho Region, which is traditionally recognized as a high incidence area.

Aim: Characterize CRC patients treated at Braga Hospital.

Methods: Data regarding clinical and preoperative diagnostic examinations, operative reports and histopathological and follow-up data was collected prospectively and stored in two Excel PC databases (colon and rectal cancer) and statistically analysed using the Statistical Package for the Social Sciences, version 19.0 (SPSS Inc., Chicago, Illinois, USA). All comparisons were examined for statistical significance using Pearson’s chi-square (χ2) test and Fisher’s exact test (when n<5), with the threshold for significance P values <0.05. Overall survival and Survival free disease were both assessed using the Kaplan-Meier method.

Results: The study comprises 672 patients with histological diagnosis of CRC treated in Braga Hospital between 2005 and 2009. It included 62.3% males and 37.7% females and most patients (60.5%) were between 61-80 years old. 65.3% of the cases arose from colon cancer and 34.7% from rectal cancer. We observed that 94.8% of the patients had no previous history of colorectal polyps. 4.1% had a previous personal history of CRC and 7.7% of a different cancer. 9.7% had a positive CRC family history. Most patients (81.3%) were symptomatic at diagnosis, while 18.8% were detected by routine colonoscopies. Colon and rectal cancer from most patients was at IIA stage and IV stage respectively. Follow-up time ranged between 1 and 5 years and, during this period, 26.7% of colon cancer patients and 25.3% of rectal cancer patients died from a colorectal cancer-related cause; also, 14.6% and 19.3% respectively had recurrence, mainly in the liver.

Conclusion: This is the first study of a large cohort of CRC patients from the Minho Region in Northern Portugal. The large majority of the 672 cases were diagnosed because symptomatic and at an advanced stage, with a relatively poor prognosis. These findings emphasize the need to start a screening program and diagnose CRC at an early stage, thus increasing cure rates and improving resource management.