A Literature Review of Concomitant Primary Biliary Cirrhosis and Gravesand#8217; Disease | OMICS International | Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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A Literature Review of Concomitant Primary Biliary Cirrhosis and Graves’ Disease

Toru Shizuma*

Department of Physiology, School of Medicine, Tokai University, Japan

*Corresponding Author:
Toru Shizuma
Department of Physiology, School of Medicine
Tokai University, 143, Shimokasuya
Isehara, Kanagawa, Japan
Tel: +81-0463-93-1121
Fax: +81-0463-93-6684
E-mail: [email protected]

Received date: December 30, 2014; Accepted date: March 27, 2015; Published date: April 04, 2015

Citation: Shizuma T (2015) A Literature Review of Concomitant Primary Biliary Cirrhosis and Graves’ Disease . J Gastrointest Dig Syst 5:269. doi:10.4172/2161-069X.1000269

Copyright: © 2015 Shizuma T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.


Although Hashimoto’s thyroiditis (HT) is commonly characterized by extrahepatic manifestations of primary biliary cirrhosis (PBC), coexistence of PBC and Graves’ disease (GD) is uncommon. This is a review of the English and Japanese scientific literature, comprising 7 cases of PBC and GD coexistence. All patients were female. In 4 cases, both diseases were almost simultaneously diagnosed, whereas PBC preceded GD in the remaining 3 cases. One fatality was observed on account of sepsis and liver failure caused by progressing PBC.


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