alexa A Pilot Study of Induction Triplet Chemotherapy Followed by Minimally Invasive Surgery for Stage 3-4 Resectable Oropharyngeal Cancer | OMICS International
ISSN: 2161-119X

Otolaryngology: Open Access
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Research Article

A Pilot Study of Induction Triplet Chemotherapy Followed by Minimally Invasive Surgery for Stage 3-4 Resectable Oropharyngeal Cancer

Krishna Rao1,2,3,4*, Kathy Robinson4, James Malone4,5, Cathy Clausen6, Bruce Shevlin6 and K Thomas Robbins4,5

1Department of Internal Medicine, Southern Illinois University School of Medicine, USA

2Division of Hematology/Oncology, Department of Internal Medicine, Southern Illinois University School of Medicine, USA

3Department of Medical Microbiology, Southern Illinois University School of Medicine, USA

4Simmons Cancer Institute at SIU, Southern Illinois University School of Medicine, USA

5Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Southern Illinois University School of Medicine, USA

6St. John’s Hospital Department of Radiation Oncology, Springfield, IL, Southern Illinois University School of Medicine, USA

*Corresponding Author:
Krishna Rao
Simmons Cancer Institute at Southern Illinois University School of Medicine
315 W. Carpenter St., PO Box 19678, Springfield, IL 62794-9678, USA
Tel: 2175457045
Fax: 2175457021
E-mail: [email protected]

Received date: Apr 10, 2015; Accepted date:: May 19, 2015; Published date:: May 26, 2015

Citation: Rao K, Robinson K, Malone J, Clausen C, Shevlin B, et al (2015) A Pilot Study of Induction Triplet Chemotherapy Followed by Minimally Invasive Surgery for Stage 3-4 Resectable Oropharyngeal Cancer . Otolaryngol (Sunnyvale) 5: 196. doi:10.4172/2161-119X. 1000196

Copyright: © 2015 Rao K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The current study reports the results of an open label pilot study evaluating a novel treatment protocol for patients with locally advanced head and neck cancer. Patients received induction chemotherapy and those who had a clinical complete response to induction chemotherapy were offered trans-oral nidusectomy for the primary lesion and neck node dissection. If a pathologic complete response was achieved, patients were then observed. Patients not achieving a clinical or pathologic complete response to induction therapy were subsequently treated with chemoradiation.

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