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Hindi A Review on Diabetic Neuropathy
*Corresponding Author:Received Date: Apr 23, 2024 / Published Date: Apr 24, 2025
Citation: Bhushan KB (2025) A Review on Diabetic Neuropathy. Epidemiol Sci 15: 598.
Copyright: © 2025 Bhushan KB. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Diabetic Peripheral Neuropathy (DPN) is a prevalent complication that affects a significant majority of individuals with both type 1 and type 2 diabetes, with a prevalence rate of over 90%. The development of DPN is primarily attributed to the toxic effects of prolonged hyperglycemia on the peripheral nerves. This condition is characterized by notable impairments in tactile sensitivity, vibration sense, lower-limb proprioception and kinesthesia. Painful DPN has been associated with a multitude of adverse consequences, including a substantial decline in overall quality of life, heightened levels of anxiety and depression, sleep disturbances and increased variability in gait. Unfortunately, DPN is often inadequately managed, underscoring the importance of improving glycemic control in diabetes management. To address the symptoms of DPN, major international clinical guidelines recommend several symptomatic treatments. First-line therapies include tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors and anticonvulsants that target calcium channels. These medications aim to alleviate pain and improve the overall functioning of individuals with DPN. Additionally, opioids and topical agents such as capsaicin and lidocaine are also considered as potential treatment options for DPN. The objectives of the present paper revolve around reviewing the current guidelines for the pharmacological management of DPN. By summarizing and examining these guidelines, healthcare professionals and researchers can gain insights into the recommended approaches for effectively addressing the symptoms of DPN and improving the overall well-being of individuals with diabetes-related neuropathy.
