alexa A Short Commentary of Neuronal Ceroid Lipofuscinoses; Phenotypes in Congenital to Preschooler
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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Short Commentary

A Short Commentary of Neuronal Ceroid Lipofuscinoses; Phenotypes in Congenital to Preschooler

Masayuki Shimono* and Ayako Senju

Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan

*Corresponding Author:
Masayuki Shimono
Department of Pediatrics
University of Occupational and Environmental Health
Iseigaoka 1-1, Yahatanishi, Kitakyushu 807-8555, Japan
Tel: +81936031611
E-mail: [email protected]

Received date: March 06, 2017; Accepted date: March 24, 2017; Published date: March 31, 2017

Citation: Shimono M, Senju A (2017) A Short Commentary of Neuronal Ceroid Lipofuscinoses; Phenotypes in Congenital to Preschooler. J Alzheimers Dis Parkinsonism 7:316. doi:10.4172/2161-0460.1000316

Copyright: © 2017 Shimono M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The classification of neuronal ceroid lipofuscinoses (NCLs) had been clinically divided according to the age at the onset of symptoms: infantile, late infantile, juvenile and adult NCLs. However, this classification cannot always predict the causative gene; i.e., CLN1, for example, causes not only infantile NCL but also late onset infantile and adult NCLs. In 2012, a new classification for the NCLs that takes into account recent genetic and biochemical advances. This short review commentary focuses on the NCLs which might cause symptoms in children from neonate to preschooler age: CLN10 (neonatal), CLN1 (6-48 months), CLN14 (8-24 months), CLN2 (1-6 years), CLN3 (4-7 years), CLN5 (4-6 years), CLN6 (18 months-8 years), CLN7 (2-7 years) and CLN8 (5-10 years). There is no fundamental therapy, but there is the trial of some cures.


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