Abstract

Hodgkin lymphoma (HL) is the most common lymphatic system cancer in teenagers and young adults (TYAs) worldwide.Several conditions that disrupt immune regulation have been linked to an increased risk of HL in TYAs.These include infectious mononucleosis (IM) following an EBV infection, HIV infection ,immunosuppressive therapy,and a number of autoimmune diseases like multiple sclerosis,systemic lupus erythematosus,and rheumatoid arthritis.Genetic studies have also found that certain HLA genes that regulate the immune system in human subjects are associated with an increased risk.