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Abnormal Brain Circuitry and Neurophysiology Demonstrated by Molecular Imaging Modalities in Schizophrenia | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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Review Article

Abnormal Brain Circuitry and Neurophysiology Demonstrated by Molecular Imaging Modalities in Schizophrenia

Ayden Jacob1*, Sharon Cohen2and Abass Alavi3

1Oxford Institute for Radiation Oncology; University of Oxford, UK

2St. Lukes Hospital, USA

3Department of Nuclear Medicine, University of Pennsylvania, USA

Corresponding Author:
Ayden Jacob
Oxford Institute for Radiation Oncology
University of Oxford, UK
E-mail: [email protected]

Received date: June 03, 2013; Accepted date: June 25, 2013; Published date: June 27, 2013

Citation: Jacob A, Cohen S, Alavi A (2013) Abnormal Brain Circuitry and Neurophysiology Demonstrated by Molecular Imaging Modalities in Schizophrenia. J Alzheimers Dis Parkinsonism 3: 114. doi: 10.4172/2161-0460.1000114

Copyright: © 2013 Jacob A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Schizophrenia is a major mental disorder characterized by functional impairment and the presentation,
persistence, and severity of symptoms. Characterized as a brain disorder, the etiology of schizophrenia remains elusive. Nevertheless, neuroimaging modalities have advanced the understanding of the neuroscientific community in regards to the structural and functional abnormalities inherent in the brains of schizophrenics. Neurochemical and molecular strategies are beginning to form a subtle consensus in the biomedical community as to the specificities of the disease on an organic level. Developing our understanding of the micro-abnormalities present in this disorder will allow the medical community to advance our neuropharmological approach to treating, curing, and perhaps preventing the onset of this disabling psychiatric disease.


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