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ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Case Report

Acrokeratosis Verruciformis of Hopf (Hopf Disease)

Hussein Salman1* and Waiel Osman2
1Dermatology Clinic, Khartoum Teaching Hospital, Khartoum, Sudan
2Registrar of dermatology, Khartoum Teaching Hospital, Khartoum, Sudan
Corresponding Author : Hussein Salman
Dermatology Clinic
Khartoum Teaching Hospital
Khartoum, Sudan
Tel: +249123094485
E-mail: [email protected]
Received December 12, 2013; Accepted January 25, 2014; Published January 30, 2014
Citation: Salman H, Osman W (2014) Acrokeratosis Verruciformis of Hopf (Hopf Disease). J Infect Dis Ther 2:128. doi:10.4172/2332-0877.1000128
Copyright: © 2014 Salman H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Acrokeratosis verruciformis of Hopf is an autosomal dominant genodermatosis usually presenting with multiple planar wart-like lesions, typically observed on the dorsum of the hands, feet, elbows, and knees. The disease is very rare and the pathogenesis remains unknown. Considerable controversy surrounds the nature and relationship of acrokeratosis and Darier disease and whether they are manifestations of one genetic abnormality. We describe the case of a 40-year-old man seen in our clinic with skin-coloured, flat, warty papules localized to the dorsum of the hands and feet. Both clinical and histological findings were compatible with acrokeratosis verruciformis. We also review the disease, particularly its relation with Darier Disease and therapeutical options.

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