Advances and Changes in the Techniques of Multi- Dimensional and Comprehensive Chromatography and When Coupled with Mass Spectrometry
Peter Baugh J*
The BMSS, C/O 23, Priory Road, Sale, M33 2BU, England, UK
- Corresponding Author:
- Peter Baugh J
Environmental and Food Analysis Special
Interest Group Leader, The BMSS, C/O 23
Priory Road, Sale, M33 2BU, England, UK
E-mail: [email protected]
Received date: June 02, 2016; Accepted date: June 20, 2016; Published date: June 27, 2016
Citation: Peter Baugh J (2016) Advances and Changes in the Techniques of Multi-Dimensional and Comprehensive Chromatography and When Coupled with Mass Spectrometry. J Anal Bioanal Tech 7:323. doi:10.4172/2155-9872.1000323
Copyright: © 2016 Peter Baugh J . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This review covers the principles of two dimensional gas and liquid chromatography (2DGC and 2DLC) and briefly introduces the theory accounting for the increase in separation resulting from a greater peak capacity than for the one dimensional (1D) mode. The advance in the techniques from multi-dimensional to comprehensive chromatography is discussed. The more recent development of multi-dimensional chromatography ion mobility mass spectrometry receives a mention to highlight the added dimension of molecular size and shape (molecular collision cross section) as an enabling tool for increasing component separation and peak capacity. Although both the techniques of 2DGC and LC are described the focus is on the environmental and food applications of 2DGC, principally when coupled to mass spectrometry, with TOFMS and HRMS as prime examples.