alexa
Reach Us +1-218-451-2974

GET THE APP

Alterations of ASL Blood Perfusion in the Thalamus and Ventral Intermediate Thalamic Nucleus in Parkinson's Disease Patients | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Alterations of ASL Blood Perfusion in the Thalamus and Ventral Intermediate Thalamic Nucleus in Parkinson's Disease Patients

Hong-Ying Zhang1, Yao Xu2, Jia-Xing Cheng2, Wen-Xin Chen1, Jing Ye1, Jing-Tao Wu1, Lan-Lan Chen2 and Jun Xu2,3*

1Department of Radiology, Subei People’s Hospital of Jiangsu Province, Yangzhou University, Yangzhou, 225001, China

2Department of Neurology, Subei People’s Hospital of Jiangsu Province, Yangzhou University, Yangzhou, 225001, China

3Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment for Senile Diseases, School of Medicine, Yangzhou University, Yangzhou, 225001, China

*Corresponding Author:
Jun Xu
Department of Neurology
Subei People’s Hospital of Jiangsu Province,
Yangzhou University, Yangzhou, 225001, China
Tel: +86 136 1157 2068
E-mail: [email protected]

Received date: September 19, 2016; Accepted date: November 01, 2016; Published date: November 08, 2016

Citation: Zhang HY, Xu Y, Cheng JX, Chen WX, Ye J, et al. (2016) Alterations of ASL Blood Perfusion in the Thalamus and Ventral Intermediate Thalamic Nucleus in Parkinson’s Disease Patients. J Alzheimers Dis Parkinsonism 6: 281. doi: 10.4172/2161-0460.1000281

Copyright: ©2016 Zhang HY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Parkinson’s disease (PD) is characterized by brain metabolic abnormalities, particularly in subcortical regions. However, previously reported observations of subcortical blood perfusion are inconsistent, especially in the thalamus. This study aimed to investigate the alterations of thalamic regional cerebral blood flow (CBF) in PD by using a recently developed advanced 3D pseudo-continuous pulse arterial spin labeling (ASL) perfusion magnetic resonance imaging approach. Twenty-three PD patients with mild-to-moderate stage disease and 29 normal control subjects underwent ASL MRI. Regional mean CBF values in the thalamus and ventral intermediate thalamic nucleus (Vim) were measured and compared between the groups by one-way analysis of variance. The PD patients showed significantly lower CBF than controls in the bilateral thalamus and Vim. Our findings indicate that hypoperfusion in the thalamus and Vim could be an imaging marker of PD.

Keywords

Recommended Conferences
Google scholar citation report
Citations : 2245

Journal of Alzheimers Disease & Parkinsonism received 2245 citations as per google scholar report

Journal of Alzheimers Disease & Parkinsonism peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page
Top