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Hindi Ameliorative Effect of Ziziphus Jujuba on Sodium Arsenite Induced Toxicity in Charles Foster Rats
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Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
In the recent times, arsenic poisoning in the ground water in the plains of the Gangetic basin has increased many folds. It is estimated that more than 300 million populations in the Ganga Meghna Brahmaputra (GMB) plains are affected due to arsenic poisoning. This has caused severe health hazards in the exposed population. In Bihar, about 18 districts out of 38 are severely affected with arsenic poisoning in ground water. The exposed population are exhibiting the typical symptoms of arsenicosis denotes the magnitude of the exposure. Hence, the present study is focused to combat the deleterious effect of arsenic toxicity in animal models utilizing medicinal plant extract. The animals (Charles Foster rats) were treated with Sodium arsenite at the dose of 8 mg per kg body weight for 16 weeks to make arsenic model and upon these arsenic pre-treated rats seed extract of Ziziphus jujuba at the dose of 250 mg per kg body weight was administered for 4 weeks to study the ameliorative effects of this plant extract. After the entire treatment, rats were sacrificed and their blood samples were obtained and analysed for haematological and biochemical study while their tissues like liver and kidney were fixed in the respective fixative for the histopathological study as well as for arsenic contamination. The study shows that arsenic induced toxicity caused deleterious effect on the rats at the haematological, biochemical and histopathological levels and there was significant normalisation in the animal at all the respective levels. Moreover, there was significant elimination from liver and kidney tissues by Z.jujuba. Hence, it possesses ameliorative properties against arsenic induced toxicity and can be used for human purpose after dose titration.
