alexa Argonaute-1 Machinery Silent Cancer Noises
ISSN: 2573-542X

Cancer Surgery
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Review Article

Argonaute-1 Machinery Silent Cancer Noises

Tanmoy Mondal1,3, Dhananjaya Pal1, Manika Pal Bhadra1* and Utpal Bhadra2*

1Centre for Chemical Biology, Indian Institute of Chemical Technology, Hyderabad, India

2Functional Genomics and Gene Silencing Group, Centre For Cellular and Molecular Biology, Hyderabad, India

3Academy of Scientific and Innovative Research, Aruna Asaf Ali Marg, New Delhi, India

*Corresponding Author:
Manika Pal Bhadra
Centre for Chemical Biology, CSIRIndian Institute of Chemical Technology
Hyderabad, India
Tel: 91 40 27193236
Email: manikapb@gmail.com
 
Utpal Bhadra
CSIR - Centre for Cellular and MolecularBiology
Hyderabad, India
Tel: 91 40 27192513
E-mail: utpal@ccmb.res.in

Received Date: February 01, 2016 Accepted Date: February 25, 2016 Published Date: March 03, 2016

Citation: Mondal T, Pal D, Bhadra MP, Bhadra U (2016) Argonaute-1 Machinery Silent Cancer Noises. Can surg 1:102. 

Copyright: © 2016 Mondal T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Small non-coding RNA mediated that is micromanaging of global gene regulation was well established as fundamental principle in cell or tissue functions. To carry out, biological role small RNA needs a unique batch of protein family named Argonaute (AGO). The Argonaute proteins carry sophisticated and highly delicate interacting modules common for three specialized small RNAs, microRNA (miRNA), short interfering RNA (siRNA) and Piwi interacting RNA (piRNA). These RNA-proteins complexes are unique to coordinate silencing events in the genome. Recent works have made a novel role of AGO1 protein by extending its tentacle towards cancer monitoring pathways. It makes a constructive bridge between a direct and constructive link between cancer and RNAi (RNA interference) machinery. Apart from multifarious classical functions such as disruption of mRNA translation, decay, transcriptional regulation and splicing, we demonstrate a new concept to narrate the role of AGO1 proteins in different cancer regulatory pathways via microRNA- Argonaute circuit specifically.

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