Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism | OMICS International | Abstract

Journal of Nutrition Science Research
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Research Article

Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism

Leonardo A Pasqua1*, Mayara V Damasceno1, Salomão Bueno1, Gustavo G de Araújo2 Adriano E Lima-Silva3 and Rômulo Bertuzzi1

1Endurance Performance Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, SP, Brazil

2Federal University of Alagoas, Sports Science Research Group, Post-Graduation in Nutrition - Department of Physical Education/CEDU, Maceio, Alagoas, Brazil

3Sport Science Research Group, Department of Physical Education and Sports Science (CAV), Federal University of Pernambuco, Vitoria de Santo Antao, PE, Brazil

*Corresponding Author:
Leonardo A Pasqua
Endurance Performance Research Group
School of Physical Education and Sport
University of São Paulo, São Paulo, SP, Brazil
Tel: 55 11 98775-5719
E-mail: [email protected]

Received date: December 04, 2015; Accepted date: February 02, 2016; Published date: February 09, 2016

Citation: Pasqua LA, Damasceno MV, Bueno S, de Araújo GG, Lima-Silva AE, et al. (2016) Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism. Sports Nutr Ther 1: 105. doi: 10.4172/2473-6449.1000105

Copyright: © 2016 Pasqua LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The purpose of this study was to verify the association between MCT1 polymorphism with physiological parameters related to aerobic fitness. A hundred fifty healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to Ventilatory Threshold (VT) and Respiratory Compensation Point (RCP). Participants were genotyped and divided in terciles based on the analyzed variables. Genotype frequencies were compared through chi-square test between lower (LT) and higher terciles (HT), with the lowest or highest values of each analyzed variable. MCT1 TT genotype was overrepresented in HT only for VT and showed a significantly higher odds ratio of belong to HT for VT compared only to AA (5.1). These results suggest that TT individuals could attain the VT and RCP at higher speeds, being able to sustain higher running speeds in lower exercise intensity domains. In other words, it is possible that individuals carrying the MCT1 TT genotype might run at higher speeds with lower fatigue signals, mimicking an inner aerobic fitness adaptation.


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