Association of Brain-Derived Neurotrophic Factor (BDNF) Gene Snps G196A and C270T with AlzheimerÃ¢ÂÂs Disease: A Meta-AnalysisShovit R and Praveen KS*
Central University of Jharkhand, Brambe, Ranchi, Jharkhand, India
- *Corresponding Author:
- Praveen KS
Centre for Life Sciences
Central University of Jharkhand, Brambe
Ranchi, Jharkhand, 835205, India
E-mail: [email protected]
Received date: April 16, 2017; Accepted date: May 03, 2017; Published date: May 10, 2017
Citation: Shovit R, Praveen KS (2017) Association of Brain-Derived Neurotrophic Factor (BDNF) Gene Snps G196A and C270T with Alzheimer’s Disease: A Meta-Analysis. J Alzheimers Dis Parkinsonism 7:323. doi:10.4172/2161-0460.1000323
Copyright: © 2017 Shovit R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To evaluate the association between diagnosis of Alzheimer’s Disease (AD) and brain-derived neurotrophic factor (BDNF) gene polymorphisms 196 G/A and 270 C/T. Methods: The authors conducted a meta-analysis along with Trial Sequential Analysis (TSA) of BDNF 196 G/A and 270 C/T polymorphisms and AD in all the available case-control studies on the topic published from 2002 to 2016. Results: Results showed no significant association between BDNF 196 G/A and 270 C/T polymorphisms and AD in overall and ethnicity specific studies. Conclusion: The present comprehensive meta-analysis suggested that further studies focusing on larger sample-size multi-ethnicity studies with homogeneous AD patients and well-matched controls are needed for future study to confirm the results of the study.