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ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Case Report

Atypical Carcinoid Tumor of the Larynx: A Challenging Diagnostic Case

Kastoer C1,2*, Vanderveken OM1,2, Lammens M2,3, Specenier P2,4, Carp L2,5, Vliet JV6, Verfaillie J1, Van de Heyning PH1,2 and Van Laer CG1,2

1Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium

2Department of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

3Department of Pathology, Wilrijkstraat, Antwerp University Hospital, Antwerp, Belgium

4Department of Oncology, Wilrijkstraat, Edegem, Antwerp University Hospital, Antwerp, Belgium

5Department of Nuclear Medicine, Wilrijkstraat, Antwerp University Hospital, Antwerp, Belgium

6Department of Otorhinolaryngology, Turnhout General Hospital, Turnhout, Antwerp, Belgium

*Corresponding Author:
Chloe Kastoer
Head and Neck Surgery
Department of Otorhinolaryngology
Antwerp University Hospital
Wilrijkstraat 10, 2650 Edegem
Antwerp, Belgium; Tel: +32038213436
Fax: +32038214271
E-mail: [email protected]

Received date: July 11, 2016; Accepted date: July 26, 2016; Published date: July 28, 2016

Citation: Kastoer C, Vanderveken OM, Lammens M, Specenier P, Carp L, et al. (2016) Atypical Carcinoid Tumor of the Larynx: A Challenging Diagnostic Case. J Clin Exp Pathol 6:287. doi:10.4172/2161-0681.1000287

Copyright: © 2016 Kastoer C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Atypical carcinoids are rare neuroendocrine tumors, but they are the most common type of nonsquamous cell laryngeal neoplasms. Recent literature addresses the importance of adequate diagnosis, but lacks consensus in treatment strategy.

Case report: A 69-year-old man presented with dysphagia. Diagnosis of supraglottic hemangioma was based on fiberoptic examination. After treatment with CO2 laser excision histopathological diagnosis stated paraganglioma. Dysphagia recurred after 6 months. (18)F-FDG PET/CT-scan revealed high FDG-uptake at the right aryepiglottic fold. After CO2 laser excision histopathology showed atypical carcinoid. Total laryngectomy and neck dissection was performed to secure tumor-free margins, followed by adjuvant radiotherapy due to lymph node metastases. A month after termination of radiotherapy no lesions were determined by somatostatin receptor scintigraphy.

Conclusion: Personalized management should be based mainly on mitotic rate and locoregional extension. Surgical treatment and lifelong multidisciplinary follow-up is mandatory, while the role of adjuvant therapy remains debatable.


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