Abstract

The chronic inflammatory illness rheumatoid arthritis (RA) is characterised by erosive polyarthritis. RA is connected with neuropsychiatric comorbidities such as depression, anxiety, and an increased risk of developing neurodegenerative disorders later in life. Studies of the central nervous system (CNS) in preclinical models of rheumatoid arthritis (RA) have contributed to the comprehension of the close interplay between peripheral and central immune responses. This mini-review outlines the current understanding of CNS comorbidity in RA patients and the known cellular processes
driving this condition.