alexa Case Report: A Rare and Unusual Cause of Acute Liver Fa
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Case Report

Case Report: A Rare and Unusual Cause of Acute Liver Failure

Nwe Ni Than1*, Frederick Chen2, Simon Olliff3 and Dhiraj Tripathi1

1Liver Unit, University Hospital NHS Trust, Birmingham, UK

2Department of Haematology, University Hospital NHS Trust & NHS Blood and Transplant, Birmingham, UK

3Interventional Radiology Department, University Hospital NHS Trust, Birmingham, UK

*Corresponding Author:
Nwe Ni Than
Liver unit, University Hospital NHS Trust
Birmingham, UK, B15 2WB
Tel: +44 7738628170

Received date: April 14, 2015; Accepted date: May 11, 2015; Published date: May 18, 2015

Citation: Than NN, Chen F, Olliff S, Tripathi D (2015) Case Report: A Rare and Unusual Cause of Acute Liver Failure . J Gastrointest Dig Syst 5:287. doi:10.4172/2161-069X.1000287

Copyright: © 2015 Than NN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Budd-Chiari syndrome (BCS) is a rare condition caused by hepatic outflow obstruction. Typical clinical features include right upper quadrant pain, ascites and hepatosplenomegaly. We report a case of a 26 year old female who presented with jaundice, worsening abdominal swelling and abdominal pain. She subsequently developed acute liver failure and spontaneous bacterial peritonitis (SBP) with significant renal impairment requiring organ support. Computed tomography (CT) scan showed congested liver and occlusion of three hepatic veins consistent with Budd- Chiari Syndrome. Transjugular intra hepatic portosystemic stent/shunt (TIPSS) was inserted which resulted in complete resolution liver and renal function. She was subsequently found to be positive for the JAK-2 V617F mutation suggesting an underlying myeloproliferative disorder. This is a rare case in which a patient developed spontaneous bacterial peritonitis (SBP) in the context of BCS. The patient had excellent outcome from TIPSS procedure, which rescued her from undergoing liver transplantation.


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