alexa Ceftriaxone-Associated Cholelithiasis in Adult Patients
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Case Report

Ceftriaxone-Associated Cholelithiasis in Adult Patients with Bacterial Meningitis

Hideto Nakajima*, Shin Ota, Takahiko Hirose, Takafumi Hosokawa, Shimon Ishida and Fumiharu Kimura
Department of Internal Medicine I, Osaka Medical College, Takatsuki, Osaka, Japan
Corresponding Author : Hideto Nakajima
Division of Neurology
Department of Internal Medicine I
Osaka Medical College, Takatsuki
Osaka 569-8686, Japan
Tel: +81-72-683-1221
Fax: +81-72-683-1801
E-mail: [email protected]
Received August 01, 2014; Accepted August 26, 2014; Published August 30, 2014
Citation: Nakajima H, Ota S, Hirose T, Hosokawa T, Ishida S, Kimura F (2014) Ceftriaxone-Associated Cholelithiasis in Adult Patients with Bacterial Meningitis. J Infect Dis Ther 2:161. doi: 10.4172/2332-0877.1000161
Copyright: © 2014 Nakajima H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Ceftriaxone is known to induce gallstones and intrabiliary debris as the adverse effects. Ceftriaxone-related cholelithiasis occurs mainly in children treated with a high dosage of ceftriaxone for severe infections and has been rarely reported in adults. Here we report two cases of bacterial meningitis, with cholelithiasis complication developed during ceftriaxone treatment. A 65 year old man and a 66 year old man were treated with long-term (3 weeks) administration of high-dose ceftriaxone (4 g/day) for bacterial meningitis. Both patients had renal dysfunction, which may have affected gallstone formation. In one patient, gallstones spontaneously disappeared after discontinuing ceftriaxone treatment. However, the other patient needed the drainage by endoscopic retrograde cholangiopancreatography. These events are associated with elevated doses of ceftriaxone and require particular attention in the elderly and patients with renal dysfunction.

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