Journal of Clinical & Experimental Pathology
Open Access

Case Report

Chordoid Glioma of the Third Ventricle with High Mib-1 Index: A Case Report

¹Bağcılar Training and Research Hospital, Department of Pathology, Istanbul, Turkey

²Department of Neuropathology, Acıbadem University, Medical Faculty, Istanbul, Turkey

³Department of Neurosurgery, Bahçeşehir University, Medical Faculty, Istanbul, Turkey

*Corresponding Author:

Altınay S
Bağcılar Eğitim ve Araştırma Hastanesi
Patoloji Laboratuvarı Merkez Mahallesi Mimar
Sinan Caddesi No:6. Bağcılar, Istanbul
Türkiye
Tel: 9002124404000
Fax: 9002124404243
E-mail: drserdara@yahoo.com

Received date: March 24, 2015 Accepted date: June 25, 2015 Published date: June 27, 2015

Citation:Altinay S, Sav A, Özduman K, Kiliç T (2015) Chordoid Glioma of the Third Ventricle with High Mib-1 Index: A Case Report. J Clin Exp Pathol 5:235. doi:10.4172/2161-0681.1000235

Copyright: ©2015 Altınay S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Chordoid glioma is a slowly growing and uncommon neoplasm which involves the third ventricle and is commonly seen in middle age woman. It is a novel entity which was just recently been incorporated to the World Health Organization (WHO) pathological central nervous system (CNS) tumor classification with chordoma like histologic features and glial fibrillary acidic protein immunoreactivity. Hereby we report a case of third ventricular chordoid glioma in a 32 year old man with history of headache and visual disturbances. Magnetic Resonance Imaging (MRI) imaging showed a homogeneously enhancing mass occupying in the third ventricle. The lesion underwent a subcapsular removal through craniotomy. Histologically the tumor had a uniform appearance consisting of clusters and cords of epithelioid cells embedded within a mucinous stroma, containing a lymphoplasmacytic infiltrate. Immunohistochemistry revealed diffuse expression of Glial Fibrillary Acidic Protein (GFAP), vimentin, cytokeratin and S-100 protein reactivity. An uncommonly high MIB-1 index of 10% was detected. There was no nuclear accumulation of p53 protein. Our patient, who rejected radiotherapy and chemotherapy options after surgery (at 52 months), is currently disease-free

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