Clinical Characteristics of Concomitant Primary Biliary Cirrhosis and Gravesand#8217; Disease: A Literature Review | OMICS International | Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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Review Article

Clinical Characteristics of Concomitant Primary Biliary Cirrhosis and Graves’ Disease: A Literature Review

Toru Shizuma*

Department of Physiology, School of Medicine, Tokai University, 143, Shimokasuya, Isehara, Kanagawa, Japan

*Corresponding Author:
Toru Shizuma
Department of Physiology, School of Medicine
Tokai University, 143, Shimokasuya, Isehara
Kanagawa, Japan
Tel: +81-0463-93-1121
Fax: +81-0463-93-6684
E-mail : [email protected]

Received date: April 22, 2015 Accepted date: June 27, 2015 Published date: July 5, 2015

Citation: Shizuma T (2015) Clinical Characteristics of Concomitant Primary Biliary Cirrhosis and Graves’ Disease: A Literature Review . J Gastrointest Dig Syst 5:303. doi:10.4172/2161-069X.1000303

Copyright: © 2015 Shizuma T. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.


Although, Hashimoto’s thyroiditis (HT) is commonly characterized by extrahepatic manifestation of PBC, the coexistence of primary biliary cirrhosis (PBC) and Graves’ disease (GD) is uncommon. Here, we conducted a review of the English and Japanese literature, including proceedings, regarding the coexistence of PBC and GD. Of 24 reviewed patients, all of who were female, there was no clear tendency of one disease to precede the other. Of two patient deaths, one was due to liver failure as a result of PBC progression.


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