Clinical Correlates of RBD in Early Parkinson Disease
- Corresponding Author:
- Astrid Haram
Ostfold Central Hospital
Department of Geriatric Psychiatry
(Alderspsykiatrisk seksjon), 1603 Fredrikstad
Tel: +47 93026972
Received date: November 04, 2014; Accepted date: December 17, 2014; Published date: December 24, 2014
Citation: Haram A, Hessen E, Auning E, Stav AL, Boeve B et al. (2014) Clinical Correlates of RBD in Early Parkinson Disease. J Alzheimers Dis Parkinsonism 4:174. doi:10.4172/2161-0460.1000174
Copyright: © 2014 Haram A et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Knowledge of the cognitive performance associated with REM sleep behavior disorder (RBD) in newly diagnosed Parkinson disease (PD) patients is limited. We thus wanted to explore 1) the frequency of RBD in patients with PD at a relatively early stage and 2) cognitive performance associated with RBD in PD. We hypothesized that RBD would be associated with cognitive impairment in PD.
Methods: 29 non-demented patients recently diagnosed with PD (disease duration<5 years, Hoehn and Yahr stage <2.5 and no dementia) were recruited. The diagnosis of PD was supported by dopamine transporter SPECT. RBD was diagnosed based on standardized clinical interview and confirmed by polysomnography. Overall cognition was assessed by screening tests including the Mini-Mental State Examination (MMSE), and neuropsychological tests of memory, language, executive, attentional and visuospatial functions tests were performed.
Results: 13 patients (45%) had probable RBD. There were no significant differences between PD with and without RBD in any of the neuropsychological tests, but a numerically lower performance was observed in the PD RBD group on memory tests
Conclusions: RBD is common even in early PD without dementia, but was not found to be associated significantly with cognition.