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Clinical Evaluation of Mucin-1 (MUC1) and P16 in Laryngeal Cancer | OMICS International| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngol (Sunnyvale) 2016, Vol 6(4): 255
  • DOI: 10.4172/2161-119X.1000255

Clinical Evaluation of Mucin-1 (MUC1) and P16 in Laryngeal Cancer

Irmi Wiest1#, Christoph Alexiou2*, Klaus Friese1, Doris Mayr3, Christoph Freier1,4, Annika Stiasny1, Peter Betz5, Marina Pöttler2, Jutta Tübel6, Steffen Goletz7, Tobias Weißenbacher1, Darius Dian1, Udo Jeschke1 and Bernd Kost2
1Department of Obstetrics and Gynecology – Klinikum Innenstadt, , Germany
2Department of Otorhinolaryngology and Head and Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON), , Germany
3Department of Pathology, , LMU, Germany
4Division of Clinical Pharmacology, LMU, , Germany
5Department of Legal Medicine, FAU, , Germany
6Department of Orthopedics, TUM, , Germany
7Glycotope, , Germany
#Contributed equally to this work
*Corresponding Author : Christoph Alexiou, Department of Otorhinolaryngology and Head and Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Glückstr. 10a Erlangen, Germany, Tel: +49 9131 85-33142, Fax: +49 9131 85-34808, Email: [email protected]

Received Date: Jul 22, 2016 / Accepted Date: Aug 05, 2016 / Published Date: Aug 11, 2016

Abstract

Background: Adapted from results in the field of cervical cancer, a direct connection between HPV infection and oropharyngeal carcinoma development could be established. Aim of this study was to evaluate p16 and TA-MUC1 in laryngeal cancer and their correlation to diagnostic, since TA-MUC1 is primarily restricted to malignancies. Methods: Paraffin-embedded laryngeal cancer specimens (n=129) and normal tissue (n=5) were analyzed for TA-MUC1 expression using hPankoMab-GEXTM antibody and evaluated according the immunoreactive score. Survival was assessed via log-rank test and Kaplan-Meier-survival analysis. Results: Significant correlation with tumor grading and staging was exhibited by TA-MUC1staining, while being negative in normal tissues. Expression of p16 significantly increased in T4 compared to T1 tumors. Significant differences in overall survival were found in correlation to TNM-classification, grading and relapse. TA-MUC1 showed a positive trend correlating to p16. Conclusion: Because of this positive trend, we suggest a HPV association in head and neck tumors. Most likely due to an insufficient quantity of HPV-positive patients, no statistical significance could be established. However, targeting TA-MUC1 would improve tumor therapy by linking hPankoMab-GEXTM to the overexpressed galectin. Systematic analysis of HPV-association should be performed generally in laryngeal cancer to gain further information about the interaction of HPV and malignancies.

Keywords: MUC-1; Laryngeal cancer; TA-MUC1; p16; Human papilloma virus (HPV); Head and neck squamous cell carcinoma (HNSCC); hPankoMab-GEXTM

Citation: Wiest I, Alexiou C, Friese K, Mayr D, Freier C, et al. (2016) Clinical Evaluation of Mucin-1 (MUC1) and P16 in Laryngeal Cancer. Otolaryngol (Sunnyvale) 6:255. Doi: 10.4172/2161-119X.1000255

Copyright: ©2016 Wiest I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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