Coexistence of Primary Biliary Cirrhosis and Immune Thrombocytopenic Purpura | OMICS International | Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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Coexistence of Primary Biliary Cirrhosis and Immune Thrombocytopenic Purpura

Toru Shizuma*

Department of Physiology, School of Medicine, Tokai University, Japan

*Corresponding Author:
Toru Shizuma
Department of Physiology
School of Medicine, Tokai University
143, Shimokasuya, Isehara, Kanagawa, Japan
Tel : +81-0463-93-1121
Fax: +81-0463-93-6684
E-mail: [email protected]

Received date: March 13, 2015, Accepted March 30, 2015, Published date: April 7, 2015

Citation: Shizuma T (2015) Coexistence of Primary Biliary Cirrhosis and Immune Thrombocytopenic Purpura . J Gastrointest Dig Syst 5:273. doi:10.4172/2161-069X.1000273

Copyright: © 2015 Shizuma T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.


Although autoimmune diseases are often concomitant, the coexistence of primary biliary cirrhosis (PBC) and immune (idiopathic) thrombocytopenic purpura (ITP) is rare. This is a review of the English-language literature regarding concomitant cases of PBC and ITP. Among 17 concomitant cases reported, including four diagnosed with Evans syndrome, which includes ITP symptoms, PBC was diagnosed first in five cases, ITP was diagnosed first in two cases, and both were almost simultaneously diagnosed in remaining 10 cases. Standard pharmacotherapy was ursodeoxycholic acid (UDCA) for PBC and corticosteroids for ITP/Evans syndrome. Among these 17 cases, one fatality was observed although there appears to be no trend for worse outcome compared with either PBC or ITP alone.


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