Construction and Immunological Evaluation of Immunostimulatory Nanocomposites with Vaccine Potential
Received Date: Oct 12, 2017 / Accepted Date: Oct 17, 2017 / Published Date: Oct 23, 2017
Abstract
For a long time, the most important means of controlling infectious diseases is prevention, and vaccination is considered the most effective measures, so the preparation and improvement of the vaccine is not only supported by the medical profession, it is the concern of the broad masses of the people. A number of biomolecules have been used as antigens to construct novel vaccine preparations, including Virus-like particles (VLPs) or bacteria, dendritic cells, nucleic acids and peptides. Immunostimulatory nanocomposites are based on the above molecules as vectors, encapsulating immune adjuvants, and nanoparticles for the construction of novel vaccines. Compared to traditional vaccines, adjuvants, nanoparticles alone, the efficacy of immunostimulatory nanocomposites as potential vaccines shows increased CD4+, CD8+ T cell count, secretion of cytokine interferon-gamma and IL-4 functions also significantly enhanced, in addition, the use of nanoparticles enhances the Immune irritation of adjuvants, VLPs and other molecules on humoral and cellular immune responses. Thus, immunostimulatory nanocomposites may be potential vaccines for future prevention and treatment applications.
Keywords: Immunostimulatory nanocomposites; Virus-like particles; Vaccine; Adjuvant; Nanoparticles; Humoral and cellular immunity
Citation: Zhuang G, Zhong M (2017) Construction and Immunological Evaluation of Immunostimulatory Nanocomposites with Vaccine Potential. J Infect Dis Ther 5:339. Doi: 10.4172/2332-0877.1000339
Copyright: © 2017 Zhong M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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