alexa
Reach Us +1-218-451-2974

GET THE APP

Cross-Roads in Research on Neurodegenerative Diseases | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Cross-Roads in Research on Neurodegenerative Diseases

Frank O Bastian*

Professor of Animal Science, Louisiana State University Agricultural Center, Baton Rouge, LA, USA

Corresponding Author:
Frank O. Bastian
Professor of Animal Science
Louisiana State University
Agricultural Center, Baton Rouge
LA 70803, LA 70803, USA
Tel: 504-610-9177
E-mail: [email protected]gcenter.lsu.edu

Received date: January 20, 2014; Accepted date: February 27, 2014; Published date: March 15, 2014

Citation: Bastian FO (2014) Cross-Roads in Research on Neurodegenerative Diseases. J Alzheimers Dis Parkinsonism 4:141. doi: 10.4172/2161-0460.1000141

Copyright: © 2014 Bastian FO. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Alzheimer’s disease (AD) is the most prevalent of the neurodegenerative amyloid diseases and is characterized by accumulation of amyloid-β and tau. Recent studies have indicated that AD may be a brain infection. Although AD has not been shown to be transmissible, the burning issue is whether the potential infectious causes are the misfolded amyloid proteins themselves, or an unidentified microorganism. The idea of a replicating protein (prion) evolved from research on the transmissible spongiform encephalopathies (TSE) represented by Creutzfeldt-Jakob disease in humans. Prions are now suspect in all of the amyloid related neurodegenerative diseases. However, the popularized prion theory is controversial since there is convincing evidence that spiroplasma, a wall-less prokaryote, is involved in the pathogenesis of TSE, and may represent the trigger mechanism. Interest in bacterial involvement in AD has surfaced from discovery that most bacteria produce biofilm and that components of the biofilm experimentally induce misfolded amyloid proteins. The recent discovery of H. pylori in AD has brought this controversy to a head. In this review we will discuss involvement of bacteria as candidate causal agent/s for the neurodegenerative diseases, and relate the evidence to involvement of spiroplasma in the pathogenesis of the TSEs as a model for these neurodegenerative diseases.

Keywords

Top