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Journal of Clinical & Experimental Pathology
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Case Report

Cytological and Histopathology Features of Meibomian Adenocarcinoma in a Dog Terrier Breed

Abbas Tavasoli1, Javad Javanbakht1*, Radmehr Shafiee2, Zahra Kamyabi-moghaddam1 and Mehdi Aghamohammad Hassan3

1Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

2Graduate Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

3Department of Clinical Science, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

*Corresponding Author:
Dr. Javad Javanbakht
Department of Pathology
Faculty of Veterinary Medicine
Tehran University, Tehran, Iran
Tel: +989372512581
E-mail: [email protected]

Received Date: May 14, 2012; Accepted Date: July 15, 2012; Published Date: July 19, 2012

Citation:Tavasoli A, Javanbakht J, Shafiee R, Moghaddam ZK, Hassan MA (2012) Cytological And Histopathology Features of Meibomian Adenocarcinoma in A Dog Terrier Breed. J Clin Exp Pathol 2:120. doi: 10.4172/2161-0681.1000120

Copyright: © 2012 Tavasoli A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In March 2012, an 8-year-old neutered terrier which was admitted to the Veterinary Surgery Clinics of Faculty of
Veterinary Medicine, University of Tehran, Iran. The signalment (i.e. description of appearance of the animals such as
sex, breed, age, etc) and anatomical repartition were summarized and focused on pathomorphological explanation.
Macroscopically, the mass was gray-reddish and arising from the right lower eyelid with local spread to the upper
eyelid and covering the entire globe was observed. Following sedation and local anesthesia, the tumor and globe were
expulsed with Cryosurgery. Cytological smears indicated large number of malignant meibomian cells occurring
either individually or in clusters also cytology indicated high cellularity and contained small clusters of polygonal to
elongated tumor cells. Microscopically, the mass was composed of lobules of various sizes separated with a septum of
connective tissue which included with poorly differentiated (grade III), nuclear pleomorphism and polygonal sebaceous
cells, also with acinular and sheet-like architecture, the findings are consistent with minimal mitotic activity, extensive
invasion, low grade and the presence of hyaline cartilage. Finally, histopathological examination revealed an MAC.


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