Delayed Distant Metastasis of Tonsillar Squamous Cell Carcinoma Origin- A Case ReportHermann Simo1, Louis De Las Casas2, Vasuki Anandan2, Michal Preis3 and Reginald Baugh4*
- Corresponding Author:
- Reginald F. Baugh
Department of Surgery
Division of Otolaryngology
The University of Toledo Medical Center
States3000 Arlington Avenue, Toledo, OH 43614, USA
E-mail: [email protected]
Received date: April 11, 2014; Accepted date: April 28, 2014; Published date: May 05, 2014
Citation: Simo H, Casas LDL, Anandan V, Preis M, Baugh R (2014) Delayed Distant Metastasis of Tonsillar Squamous Cell Carcinoma Origin- A Case Report. Otolaryngology 4:170 doi:10.4172/2161-119X.1000170
Copyright: © 2014 Simo H et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: The incidence of distant metastases from head and neck Squamous Cell Carcinoma (SCC) is reportedly low; reports of distant metastases from tonsil carcinoma are rare. 85% of distant metastases of SCC in head and neck cancers usually become apparent within two years of primary diagnosis, but can take up to five years before diagnosis.
Background: Metastases from tonsillar cancers are uncommon, with less than 1% reported to go to subcutaneous tissues. Metastases are reported to occur within 1-48 months after initial treatment.
Methods and results: A case report is presented of a patient seen with an isolated temporal scalp Squamous Cell Carcinoma (SCC) lesion 8 years after treatment for a tonsillar SCC and negative annual PET scans thereafter. The comparative immunehistochemical study and in situ hybridization done between the scalp tumor and the previous tonsil tumor eight years earlier, showed similarities, thus suggesting a metastasis from the tonsil tumor.
Conclusions: A tonsillar SCC metastasis presenting as a temporal scalp lesion 8 years after primary tumor treatment and locoregional control achievement is a uniquely rare event. The case highlights the need for a method to identify and track tumor cell lineage, and the need for better understanding of cancer stem cells role in head and neck SCC.