Determination of Tinidazole and Ciprofloxacin Hydrochloride in Single Formulation Tablet using Differential Pulse PolarographySalvi V S*, Sathe P A and Rege P V
Department of chemistry, Ramnarain Ruia College, Mumbai-400 019, India
- *Corresponding Author:
- V S Salvi
Department of chemistry
Ramnarain Ruia College
Mumbai– 400 019, India
E-mail: [email protected]
Received date: October 19, 2010; Accepted date: November 24, 2010; Published date: November 26, 2010
Citation: Salvi VS, Sathe PA, Rege PV (2010) Determination of Tinidazole and Ciprofloxacin Hydrochloride in Single Formulation Tablet using Differential Pulse Polarography. J Anal Bioanal Tech 1:110. doi: 10.4172/2155-9872.1000110
Copyright: © 2010 Salvi VS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A simple and precise method for the determination of Tinidazole and Ciprofloxacin hydrochloride from its single formulation tablet has been developed using differential pulse polarography. Tinidazole and ciprofloxacin produces a cathodic wave at -0.38 V and -1.30 V respectively versus S.C.E in a solution of pH = 6.5 (Britton Robison buffer). The dynamic range for Tinidazole, is 0.50 to 279.31μgcm -3 and for Ciprofloxacin, it is 24.39 to 245.28 μgcm -3 . The method has been validated and applied successfully for the determination of the two drugs from their respective formulation.