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Development and Validation of Spectrophotometric Method for Determination of Finasteride in Pharmaceutical Formulation Using 1,2-Naphthoquine-4-sulfonate (NQS) | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Research Article

Development and Validation of Spectrophotometric Method for Determination of Finasteride in Pharmaceutical Formulation Using 1,2-Naphthoquine-4-sulfonate (NQS)

Sally Mohammed Ahmed and Abdalla Ahmed Elbashir*

University of Khartoum, Faculty of Science, Chemistry Department, Khartoum, Sudan

*Corresponding Author:
Abdalla Ahmed Elbashir
University of Khartoum, Faculty of Science
Chemistry Department
Khartoum, Sudan
Tel: 5661431-431
E-mail: [email protected]

Received date: May 04, 2015; Accepted date: May 22, 2015; Published date: May 29, 2015

Citation: Ahmed SM and Elbashir AA (2015) Development and Validation of Spectrophotometric Method for Determination of Finasteride in Pharmaceutical Formulation Using 1,2-Naphthoquine-4-sulfonate (NQS). J Anal Bioanal Tech 6:247. doi: 10.4172/2155-9872.1000248

Copyright: © 2015 Ahmed SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A rapid, simple and sensitive method for the determination of finasteride using sodium 1,2-naphthoquine-4- sulfonate (NQS) has been developed. The method is based on the fact that a brown product can be formed by the reaction between finasteride and sodium NQS in a buffer solution of a pH 13.0. Beer’s law is obeyed in the range 2-14 μg/ml of finasteride at maximum wavelength of 447 nm. The linear regression equation of the calibration curve is y=0.062857x+0.069857, with a linear regression correlation coefficient of 0.999. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.03 and 0.09 μg/ml, respectively. The method has been successfully applied to the determination of finasteride in pharmaceutical formulation. The results were in good agreement with those obtained with the official high performance liquid chromatography (HPLC) method. The proposed method is useful for routine analysis of finasteride in quality control laboratories.

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