alexa Diagnosing Progressive Supranuclear Palsy: Role of Biological and Neuroimaging Markers
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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Review Article

Diagnosing Progressive Supranuclear Palsy: Role of Biological and Neuroimaging Markers

Borroni B1*, Benussi A1, Pilotto A1, Gazzina S1, Turrone R1, Gardoni F2, Di Luca M2 and Padovani A1

1Centre for Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy

2Centre of Excellence in Neurodegenerative Disorders, University of Milan, Milan, Italy

Corresponding Author:
Barbara Borroni
Clinica Neurologica
Università degli Studi di Brescia Pza Spedali Civili, 1 - 25100 Brescia, Italy
Tel: +39-0303995632;
Email: [email protected]

Received date: August 04, 2014; Accepted date: November 05, 2014; Published date: November 12, 2014

Citation: Borroni B, Benussi A, Pilotto A, Gazzina S, Turrone R et al. (2014) Diagnosing Progressive Supranuclear Palsy: Role of Biological and Neuroimaging Markers. J Alzheimers Dis Parkinsonism 4:168. doi: 10.4172/2161-0460.1000168

Copyright: 2014 Borroni B et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorders characterised by a kinetic-rigid syndrome with ocular motor dysfunction, postural instability, and frontal lobe and bulbar dysfunction. In most of the cases, especially at early disease stages, diagnosis is still challenging. PSP signs and symptoms may indeed overlap with both dementing neurodegenerative syndromes and movement disorders. In the last few years, a better definition of clinical picture along with the identification of biological and neuroimaging markers have increased diagnostic accuracy. In the present work, we reviewed the current literature on PSP diagnosis and the usefulness of potential diagnostic markers.

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