ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngol (Sunnyvale) 2015, Vol 5(5): 208
  • DOI: 10.4172/2161-119X.1000208

Differences in Acetic Acid Ototoxicity in Guinea Pigs are Dependent on Maturity

Takafumi Yamano*, Hitomi Higuchi2, Tetsuko Ueno2, Takashi Nakagawa2 and Tetsuo Morizono3
1Section of Otorhinolaryngology, Department of Medicine, Fukuoka Dental College, , Japan
2Department of Otorhinolaryngology, Fukuoka University School of Medicine, , Japan
3Department of Otorhinolaryngology, Fukuoka University School of Medicine, , Nishi Fukuoka Hospital, Japan
*Corresponding Author : Takafumi Yamano, Section of Otorhinolaryngology, Department of Medicine, Fukuoka Dental College, Japan, Tel: 81-92-801-0411, Fax: 81-92-801-3678, Email: yamano@college.fdcnet.ac.jp

Abstract

Objectives: The objective was to study if the difference exist in drug ototoxicity between less mature and mature guinea pigs.

Methods: The matured animal group had a body weight of 400 g and the less mature animal group had a body weight of 200 g. After compound action potential of the eight cranial nerves was measured, the middle ear cavity was filled with acetic acid.

Results: The less mature animal group was more sensitive to the acetic acid treatment than the more mature animal group.

Conclusion: We suggest that a difference in ototoxicity of certain otic drop treatments may exist between pediatric and adult patients.

Keywords: Ototoxicity, Acetic acid, maturity, Guinea pig

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