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Dimensions of DNA Damage Recognition are Key Events in Inducing Complementary Multi-Pathway Repair Response in Potentiating Tumor Therapeutic Resistance| Abstract
ISSN: 2161-1165

Epidemiology: Open Access
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  • Mini Review   
  • Epidemiology (Sunnyvale) 2018, Vol 8(2): 341
  • DOI: 10.4172/2161-1165.1000341

Dimensions of DNA Damage Recognition are Key Events in Inducing Complementary Multi-Pathway Repair Response in Potentiating Tumor Therapeutic Resistance

Lawrence M Agius*
Department of Pathology, Mater Dei Hospital, Tal-Qroqq, University Of Malta Medical School, , Msida, Europe, Malta
*Corresponding Author : Lawrence M Agius, Department of Pathology, Mater Dei Hospital, Tal-Qroqq, University Of Malta Medical School, Msida, Europe, Malta, Tel: +356-21451752, Email: [email protected]

Received Date: Jun 20, 2018 / Accepted Date: May 07, 2018 / Published Date: May 16, 2018

Abstract

Dimensional resolution of malignant transformation events in cells is a putative reflection of susceptibility hot spots in DNA biology of response to genomic damage. It is further to such understanding that repair processes are potentially a vast array of complementary pathways that significantly promote the resistance to therapeutic attempts at cancerous lesion ablation. Sufficient promotional repair of single-strand and double-strand breaks may subsequently compromise susceptibility to therapy once cell replication is initiated. The toxic nature of abasic sites is a prime example for a need for selective phase susceptibility during the cell cycling of tumor cells to engineered or natural chemotherapeutic agents or to ionizing radiation.

Keywords: Dimensions; DNA damage; Lethality

Citation: Agius LM (2018) Dimensions of DNA Damage Recognition are Key Events in Inducing Complementary Multi-Pathway Repair Response in Potentiating Tumor Therapeutic Resistance. Epidemiology (Sunnyvale) 8:341. Doi: 10.4172/2161-1165.1000341

Copyright: © 2018 Agius LM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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