alexa Dopaminergic Positron Emission Tomography Study on Amyotrophic Lateral Sclerosis/Parkinsonism–Dementia Complex in Kii, Japan
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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Research Article

Dopaminergic Positron Emission Tomography Study on Amyotrophic Lateral Sclerosis/Parkinsonism–Dementia Complex in Kii, Japan

Yasumasa Kokubo1*, Kenji Ishii2, Satoru Morimoto3, Maya Mimuro4, Ryogen Sasaki5, Shigeo Murayama3 and Shigeki Kuzuhara6

1Kii ALS/PDC Research Center, Mie University Graduate School of Regional Innovation Studies, Japan

2Department of Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Japan

3Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Japan

4Institute for Medical Science of Aging, Aichi Medical University, Japan

5Department of Neurology, National Mie Hospital, Japan

6Department of Neurology and Medicine, Medical Welfare, Suzuka University of Medical Science, Japan

*Corresponding Author:
Yasumasa Kokubo
Kii ALS/PDC Research Center
Mie University, Graduate School of Regional Innovation Studies
Mie 514-8507, Japan
Tel: +81 59 231 5117
E-mail: [email protected]

Received date: February 06, 2017; Accepted date: February 28, 2017; Published date: March 07, 2017

Citation: Kokubo Y, Ishii K, Morimoto S, Mimuro M, Sasaki R, et al. (2017) Dopaminergic Positron Emission Tomography Study on Amyotrophic Lateral Sclerosis/Parkinsonism–Dementia Complex in Kii, Japan. J Alzheimers Dis Parkinsonism 7:311. doi:10.4172/2161-0460.1000311

Copyright: © 2017 Kokubo Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Amyotrophic lateral sclerosis and parkinsonism-dementia complex in the Kii peninsula, Japan (Kii ALS/PDC) is an endemic and rare neurodegenerative disease. We conducted positron emission tomography (PET) study using C-11 CFT (2-b-carbomethoxy-3b-(4-fluorophenyl) tropane) and C-11 Raclopride for two patients with Kii ALS/PDC. Objective and methods: Patient #1 was 64 years old male having 12 years’ duration of the illness. Patient #2 was 68 years old female having 7 years’ duration of the illness. Results: In patient #1, CFT-PET showed marked decreased uptake in the bilateral corpus striatum, almost no signal in the posterior part of the putamen. RAC-PET showed mild decrease in the bilateral caudate nucleus and slight increase in the posterior part of the putamen. In patient #2, CFT-PET showed severe decrease in the bilateral corpus striatum, marked decrease in the posterior part of the putamen and in the caudate nucleus. RACPET showed the mild decrease in the bilateral corpus striatum. Conclusion: These results were compatible with L-dopa resistant Parkinsonism and similar to those of PSP.

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