ISSN: 2476-2024

Diagnostic Pathology: Open Access
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  • Research Article   
  • Diagn Pathol Open 2016, Vol 1(2): 111
  • DOI: 10.4172/2476-2024.1000111

Dysadherin Expression is Associated with Advanced Tumorstage while Complexity Index is Related to Poorly Differentiated Tumors in Colon Carcinoma

Abdul Mannan1 and Victoria Hahn-Stromberg1,2*
1Department of Clinical Research, Faculty of Medicine and Health SE 70182 Örebro, , Sweden
2Department of Medical Cell Biology, Uppsala University, Uppsala, 75105, Sweden
*Corresponding Author : Victoria Hahn-Stromberg, Department of Medical Cell Biology, Uppsala University, Uppsala, 75105, Sweden, Email: victoriastromberg@hotmail.com

Received Date: Apr 08, 2016 / Accepted Date: Apr 21, 2016 / Published Date: Apr 25, 2016

Abstract

Dysadherin expressions are associated with the aggressive tumors that show poor prognosis in different types of cancers. Aggressive tumors often presented with infiltrative type of growth pattern in colon cancer and that has been associated with poor prognosis as well. The aim of this was to evaluate Dysadherin expression in paired normal and tumor samples, and tumor growth pattern in the form of complexity index in the same patient colon cancer samples, and finally to correlate with each other and different clinical and pathological parameters. To evaluate Dysadherin expression, we selected 45 patients and performed RT-qPCR on normal and paired tumor samples. To determine growth pattern, we captured pictures from the immunohistochemically stained tumor invasive fronts and then evaluated by using Photoshop CS, Fovea Pro, and Image J computer programs. Paired t test was applied for the Dysadherin expression between normal and paired normal samples while Pearson chi square and Fischer exact test between dichotomized Dysadherin expression, complexity index and different clinicopathological parameters. Mean Dysadherin expression in normal samples was 0.155+0.0167 and in tumor 0.869+0.083 and was significantly different between two groups of samples (P value<0.0001). In dichotomized groups, increased Dysadherin expression was significantly correlated with the lymph node metastasis and advanced Dukes stages. Higher complexity index was significantly associated with low differentiated tumors while non-significantly with other clinicopathological parameters. In conclusion, Dysadherin expression and tumor growth pattern are independent features, where Dysadherin expression is associated with advanced Dukes staged tumors and complexity index with the poorly differentiated tumors.

Keywords: Complexity index; Dysadherin; Clinicopathological parameters; Tumor node metastasis

Citation: Mannan A, Hahn-Stromberg V (2016) Dysadherin Expression is Associated with Advanced Tumorstage while Complexity Index is Related to Poorly Differentiated Tumors in Colon Carcinoma. Diagn Pathol Open 1:111. Doi: 10.4172/2476-2024.1000111

Copyright: © 2016 Mannan A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review summary

  1. Nakao Shamu
    Posted on Aug 24 2016 at 11:29 am
    Although many studies have been reported an increased Dysadherin protein expression, but none of the conducted studies have evaluated the quantitative change in Dysadherin mRNA level. Furthermore, due to its effect on lowering cellular adhesion, increased Dysadherin expression may alter the growth pattern of the tumor. Therefore, in this study the authors evaluated the expression of Dysadherin in paired normal and tumour colon cancer samples and also estimated complexity index of the tumor. This study suggests that Dysadherin and complexity indexes are independent factors associated with the aggressiveness of colon carcinoma and could be used as prognostic markers.
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