Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Dysregulation of microRNAs Across Oral Squamous Cell Carcinoma Fields in Non-smokers | OMICS International | Abstract
ISSN: 2376-032X

JBR Journal of Interdisciplinary Medicine and Dental Science
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Dysregulation of microRNAs Across Oral Squamous Cell Carcinoma Fields in Non-smokers

Rebecca Towle1#, Mike Gorenchtein1#, Christopher Dickman1, Yuqi Zhu2, Catherine F. Poh1,2 and Cathie Garnis1,3*

1Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada

2Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada

3Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC, Canada

#These two authors equally contributed to this study.

Corresponding Author:
Cathie Garnis, PhD
BC Cancer Research Centre, 675 West 10th Avenue
Vancouver, BC, V5Z 1L3, Canada
Tel: 604-675-8000
Fax: 604-675-8283

Received date: May 06, 2014; Accepted date: June 30, 2014; Published date: July 07, 2014

Citation: Towle R, Gorenchtein M, Dickman C, Zhu Y, Poh CF, et al. (2014) Dysregulation of microRNAs Across Oral Squamous Cell Carcinoma Fields in Non-smokers. J Interdiscipl Med Dent Sci 2:131. doi:10.4172/2376-032X.1000131

Copyright: © 2014 Garnis, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: The main etiological factor for oral squamous cell carcinoma (OSCC) is tobacco use; however nonsmoking cases have also been reported. The molecular basis of emerging oral malignancy in non-smokers is poorly understood. We seek to profile the microRNA patterns in this subset of patients.

Methods: We evaluated global microRNA expression in multiple biopsies representing varied stages of oral cancer/pre-cancer taken from a single, contiguous field of diseased oral tissue.

Results: We find distinct lists of frequently deregulated microRNA in each field. MiR-155 was selected for further validation in an independent cohort comprised of tissues from smokers and non-smokers. Highly expressed miR-155 was identified in 58% of OSCC cases and 83% of dysplasia cases.

Conclusions: We conclude that miR-155 may be a driver of oral tumorigenesis and that molecular heterogeneity across fields of diseased tissue has significant implications when selecting candidates for development of targeted therapies.


Indexed In
  • Index Copernicus
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • Geneva Foundation for Medical Education and Research
Recommended Journals
Related Subjects
Share This Page