Dysregulation of microRNAs Across Oral Squamous Cell Carcinoma Fields in Non-smokers
- Corresponding Author:
- Cathie Garnis, PhD
BC Cancer Research Centre, 675 West 10th Avenue
Vancouver, BC, V5Z 1L3, Canada
Received date: May 06, 2014; Accepted date: June 30, 2014; Published date: July 07, 2014
Citation: Towle R, Gorenchtein M, Dickman C, Zhu Y, Poh CF, et al. (2014) Dysregulation of microRNAs Across Oral Squamous Cell Carcinoma Fields in Non-smokers. J Interdiscipl Med Dent Sci 2:131. doi:10.4172/2376-032X.1000131
Copyright: © 2014 Garnis, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: The main etiological factor for oral squamous cell carcinoma (OSCC) is tobacco use; however nonsmoking cases have also been reported. The molecular basis of emerging oral malignancy in non-smokers is poorly understood. We seek to profile the microRNA patterns in this subset of patients.
Methods: We evaluated global microRNA expression in multiple biopsies representing varied stages of oral cancer/pre-cancer taken from a single, contiguous field of diseased oral tissue.
Results: We find distinct lists of frequently deregulated microRNA in each field. MiR-155 was selected for further validation in an independent cohort comprised of tissues from smokers and non-smokers. Highly expressed miR-155 was identified in 58% of OSCC cases and 83% of dysplasia cases.
Conclusions: We conclude that miR-155 may be a driver of oral tumorigenesis and that molecular heterogeneity across fields of diseased tissue has significant implications when selecting candidates for development of targeted therapies.