alexa Effect of CBT on Depressive Symptoms in Methadone Maintenance Patients Undergoing Treatment for Hepatitis C
ISSN: 2155-6105

Journal of Addiction Research & Therapy
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Research Article

Effect of CBT on Depressive Symptoms in Methadone Maintenance Patients Undergoing Treatment for Hepatitis C

Susan E. Ramsey1,4*, Patricia A. Engler1,4, Michael D. Stein1,5, Richard A. Brown1,5, Patricia Cioe4, Christopher W. Kahler2, Kittichai Promrat1, Jennifer Rose3, Jennifer Anthony1,4 and David A. Solomon1,4

1The Warren Alpert Medical School of Brown University, USA

2Brown University Center for Alcohol and Addiction Studies, USA

3Wesleyan University, USA

4Rhode Island Hospital, USA

5Butler Hospital, USA

*Corresponding Author:
Susan E. Ramsey
The Warren Alpert Medical School of Brown University
Rhode Island Hospital, Division of General Internal Medicine
593 Eddy Street, Providence, RI 02903, USA
Tel: 401-444-7831
Fax: 401-444-5040

Received February 04, 2011; Accepted May 10, 2011; Published May 13, 2011

Citation: Ramsey SE, Engler PA, Stein MD, Brown RA, Cioe P et al. (2011) Effect of CBT on Depressive Symptoms in Methadone Maintenance Patients Undergoing Treatment for Hepatitis C. J Addict Res Ther 2:109. doi:10.4172/2155-6105.1000109

Copyright: © 2011 Ramsey SE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


To examine the efficacy of a cognitive-behavioral intervention (CBT) to prevent depression among methadone maintenance patients undergoing antiviral treatment for hepatitis C (HCV), 29 patients beginning HCV treatment were randomized to CBT or standard care (SC). Study participants did not meet criteria for major depressive disorder at the time of study recruitment. CBT did not result in less depression-related antiviral treatment failure, better adherence to antiviral treatment, or better HCV RNA outcomes. There were no significant treatment group differences on depressive symptoms over time. The CBT group did display a greater and more consistent decline in both BDI-II and HAM-D scores over time (d=.85 on the BDI-II; d=.72 on the HAM-D).


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